DYRK3 Antibodies

AND DYRK3 ELISA kits, DYRK3 Proteins

Many biological assays use antibodies to detect DYRK3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DYRK3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DYRK3 antibodies...

We validate the specificity of these antibodies to DYRK3 by testing them on tissues known to express DYRK3 positively and negatively. Browse below to find the DYRK3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DYRK3 Infographic by Boster Bio

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Anti-DYRK3 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A04782
100ul

DYRK3 Overview

Facts about Dual specificity tyrosine-phosphorylation-regulated kinase 3.

DYRK3 3D structure. Source: alphafold

Dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3)

Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (PubMed:29973724). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate an essential tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues (PubMed:9748265, PubMed:29634919).

Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear- envelope breakdown: functions by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 (PubMed:29973724). Doesn't mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus isn't governed by DYRK3 (PubMed:29973724).

Gene Information

Human
Gene Name:	DYRK3
Uniprot:	O43781
Entrez:	8444

Family

Belongs to:

protein kinase superfamily

Alternative Names

dual specificity tyrosine-phosphorylation-regulated kinase 3; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5; DYRK3; DYRK5; EC 2.7.12; EC 2.7.12.1; hYAK3-2; protein kinase Dyrk3; REDK; REDKRED; Regulatory erythroid kinase; YAK3-2

Molecular Weight

Mass (kDA):
65.714 kDA

Genomic Context


Human

Location:	1q32.1
Sequence:	1; NC_000001.11 (206635536..206655175)

Tissue Specificity

Isoform 1: Highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow (PubMed:10779429). Isoform 1: Predominant form in fetal liver and bone marrow (PubMed:10779429). Isoform 1: Present at low levels in heart, pancreas, lymph node and thymus (PubMed:10779429). Isoform 2: Highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow (PubMed:10779429). Isoform 2: Predominant form in testis. Isoform 2: Present at low levels in heart, pancreas, lymph node and thymus (PubMed:10779429).

Subcellular Localizations

Nucleus. Cytoplasm. Nucleus speckle. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Associates with membraneless organelles in the cytoplasm and nucleus (PubMed:29973724). Shuttles between cytoplasm and stress granules (PubMed:20167603). Localized predominantly on distinct speckles distributed throughout the cytoplasm of the cell (PubMed:20167603). At low concentration, showns a homogeneous distribution throughout the cytoplasm and does not condense in speckles. During oxidative and osmotic stress, localizes to stress granules (PubMed:20167603).

Diseases

Down Syndrome
Cell Invasion
Neoplasms
Infection By Cryptococcus Neoformans
Glioma
Neoplasm Invasiveness
Malignant Neoplasm Of Lung
Meningoencephalitis
Patient Dependence On
Malignant Neoplasms
Adenocarcinoma
Cell Transformation, Neoplastic

Lung Neoplasms
Anemia
Chromosomal Duplication
Non-small Cell Lung Carcinoma
Malignant Paraganglionic Neoplasm
Tissue Adhesions
Malignant Glioma

Pathways

Cell Proliferation
Brain Development
Cell Death
Protein Phosphorylation
Programmed Cell Death
Cell Development
Aging
Pigmentation
Neurogenesis
Endocytosis
Localization

Cell Division
Flight
Sperm Motility
Cell Differentiation
Cell Growth
Rna Interference

PTMs

Phosphorylation

Dephosphorylation

Deacetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DYRK3

References

PMID: 9748265 by Becker W., et al. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases.

PMID: 9845759 by Xia J., et al. Molecular cloning and characterization of novel protein kinase gene DYRK3.