DOCK4 Antibodies

AND DOCK4 ELISA kits, DOCK4 Proteins

Many biological assays use antibodies to detect DOCK4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DOCK4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DOCK4 antibodies...

We validate the specificity of these antibodies to DOCK4 by testing them on tissues known to express DOCK4 positively and negatively. Browse below to find the DOCK4 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DOCK4 Infographic by Boster Bio

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Anti-DOCK4 Antibody Picoband®

Human, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A05916-1
100 μg/vial

DOCK4 Overview

Facts about Dedicator of cytokinesis protein 4.

DOCK4 3D structure. Source: alphafold

Dedicator of cytokinesis protein 4 (DOCK4)

Involved in regulation of adherens junction between cells. Plays a role in cell migration.

Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. .

Gene Information

Human
Gene Name:	DOCK4
Uniprot:	Q8N1I0
Entrez:	9732

Family

Belongs to:

DOCK family

Alternative Names

dedicator of cytokinesis 4; dedicator of cytokinesis protein 4; KIAA0716FLJ34238; MGC134911; MGC134912

Molecular Weight

Mass (kDA):
225.206 kDA

Genomic Context


Human

Location:	7q31.1
Sequence:	7; NC_000007.14 (111726110..112206399, complement)

Tissue Specificity

Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary.

Subcellular Localizations

Cell membrane. Cell projection. Cytoplasm, cytosol. Colocalizes with EPHA2, RhoG and CTTN/cortactin at the tip of protrusions in migrating cells.

Diseases

Neoplasms
Malignant Neoplasms
Cell Invasion
Autistic Disorder
Autism Spectrum Disorders
Neoplasm Metastasis
Dyslexia
Myeloid Leukemia
Tumor Progression
Malignant Neoplasm Of Ovary
Dysmyelopoietic Syndromes
Leukemia
Learning Disorders

Fracture Of First Cervical Vertebra
Developmental Reading Disorder
Ovarian Serous Adenocarcinoma
Malignant Neoplasm Of Breast
Myeloid Leukemia, Chronic
Pancytopenia
Sarcoma

Pathways

Cell Migration
Pathogenesis
Actin Cytoskeleton Organization
Programmed Cell Death
Dendrite Development
Cell-matrix Adhesion
Endocytosis
Histone Modification
Localization
Cytokinesis
Drug Resistance
Cytoskeleton Organization
Reverse Transcription

Chemotaxis
Cell Cycle
Cell Motility
Cell Death
Regulation Of Cell Migration
Dedifferentiation
Cell Growth

PTMs

Phosphorylation

Biotinylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DOCK4

References

PMID: 12628187 by Yajnik V., et al. DOCK4, a GTPase activator, is disrupted during tumorigenesis.

PMID: 12432077 by Cote J.-F., et al. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity.