DNAJC6 Antibodies

AND DNAJC6 ELISA kits, DNAJC6 Proteins

Many biological assays use antibodies to detect DNAJC6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNAJC6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNAJC6 antibodies...

We validate the specificity of these antibodies to DNAJC6 by testing them on tissues known to express DNAJC6 positively and negatively. Browse below to find the DNAJC6 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DNAJC6 Infographic by Boster Bio

All DNAJC6 Products

Product

Figures

Specificity

Applications

Price

Anti-DNAJC6 Antibody Picoband™

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A05616-2
100 μg/vial

DNAJC6 (NM_014787) Human Over-expression Lysate

Human

$960
Cat # LS009829
100 µg

DNAJC6 Overview

Facts about Putative tyrosine-protein phosphatase auxilin.

DNAJC6 3D structure. Source: alphafold

Putative tyrosine-protein phosphatase auxilin (DNAJC6)

Recruits HSPA8/HSC70 into clathrin-coated vesicles and boosts uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity).

Gene Information

Human
Gene Name:	DNAJC6
Uniprot:	O75061
Entrez:	9829

Family

Belongs to:

No superfamily

Alternative Names

DJC6; DnaJ (Hsp40) homolog, subfamily B, member 6; DnaJ (Hsp40) homolog, subfamily C, member 6; DnaJ homolog subfamily C member 6; EC 3.1.3.48; KIAA0473auxilin; MGC129914; MGC129915; MGC48436; putative tyrosine-protein phosphatase auxilin

Molecular Weight

Mass (kDA):
99.997 kDA

Genomic Context


Human

Location:	1p31.3
Sequence:	1; NC_000001.11 (65264694..65415871)

Tissue Specificity

Expressed in various brain regions, including cerebellum, corpus callosum, cortex, striatum, brainstem, pons, putamen, spinal cord and substantia nigra. Very low expression in non-neural tissues such as leukocytes, liver, adipose tissue, skeletal muscle and bone marrow.

Diseases

Refractory Neutropenia
Spinocerebellar Ataxia Type 5
Nerve Degeneration
Neurodegenerative Disorders
Thrombophilia
Ataxia
Thromboembolism
Parkinson Disease
Epilepsy
Juvenile Parkinson's Disease
Venous Thromboembolism
Obesity

Protein S Deficiency
Secondary Parkinson Disease
Wallerian Degeneration
Chimera Disorder
Ataxia, Spinocerebellar
Huntington Disease

Pathways

Pathogenesis
Blood Coagulation
Coagulation
Synaptic Transmission
Endocytosis
Localization

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DNAJC6

References

PMID: 22563501 by Edvardson S., et al. A deleterious mutation in DNAJC6 encoding the neuronal-specific clathrin-uncoating co-chaperone auxilin, is associated with juvenile parkinsonism.

PMID: 23211418 by Koroglu C., et al. DNAJC6 is responsible for juvenile parkinsonism with phenotypic variability.