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DNAJB9 Antibodies
AND DNAJB9 ELISA kits, DNAJB9 Proteins
Many biological assays use antibodies to detect DNAJB9, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNAJB9 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNAJB9 antibodies...
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DNAJB9 Overview
Facts about DnaJ homolog subfamily B member 9.
DnaJ homolog subfamily B member 9 (DNAJB9)
Co-chaperone for Hsp70 protein HSPA5/BiP that functions as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946).
In the unstressed endoplasmic reticulum, interacts with the luminal area of ERN1/IRE1 and recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal area, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins.
Gene Information
| Human | |
|---|---|
| Gene Name: | DNAJB9 |
| Uniprot: | Q9UBS3 |
| Entrez: | 4189 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
DKFZp564F1862; DnaJ (Hsp40) homolog, subfamily B, member 9; dnaJ homolog subfamily B member 9; endoplasmic reticulum DnaJ homolog 4; ERdj4; Mdg-1; MDG1MSTP049; Microvascular endothelial differentiation gene 1 protein; MST049
Molecular Weight
Mass (kDA):
25.518 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q31.1|14q24.2-q24.3 |
| Sequence: | 7; NC_000007.14 (108569874..108574850) |
Tissue Specificity
Widely expressed. Expressed at highest level in the liver, placenta and kidney (PubMed:11836248).
Subcellular Localizations
Endoplasmic reticulum lumen.
Diseases
- Malignant Neoplasms
- Neoplasms
- Physiological Stress
- Endoplasmic Reticulum Stress
- Tumor Angiogenesis
- Stomach Neoplasms
- Malignant Neoplasm Of Breast
- Scleroderma
- Hepatitis B
- Posterior Reversible Encephalopathy Syndrome
- Lung Diseases
- Inflammatory Response
Pathways
- Cell Proliferation
- Cell Cycle Arrest
- Cell Cycle
- Protein Folding
- Cell Differentiation
- Angiogenesis
- Regulation Of Cell Cycle
- Cell Migration
- Glycosylation
- Vasculogenesis
- Negative Regulation Of Cell Cycle
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DNAJB9
bosterbio.com/bosterbio-gene-info-cards/DNAJB9
References
PMID: 11836248 by Shen Y., et al. Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress.
PMID: 18400946 by Dong M., et al. ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C.