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- Table of Contents
10 Q&As
Facts about Dickkopf-related protein 3.
In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). .
Human | |
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Gene Name: | DKK3 |
Uniprot: | Q9UBP4 |
Entrez: | 27122 |
Belongs to: |
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dickkopf family |
dickkopf (Xenopus laevis) homolog 3; dickkopf 3; dickkopf homolog 3 (Xenopus laevis); Dickkopf-3; dickkopf-related protein 3; Dkk3; Dkk-3; hDkk-3; regulated in glioma; REIC; REICdkk-3; RIG; RIG-like 5-6; RIG-like 7-1
Mass (kDA):
38.39 kDA
Human | |
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Location: | 11p15.3 |
Sequence: | 11; NC_000011.10 (11962979..12009827, complement) |
Highest expression in heart, brain, and spinal cord.
Secreted.
The DKK3 marker is one of the most commonly used markers in immunohistochemistry, but how can it be used in other applications? Here are some tips. Scientists using the DKK3 marker should know about the DKK3 tyrosine kinase domain (TKD) in their research. Scientists can submit results for special species, applications, and species studies. They can receive product credits for their findings. This DKK3 marker is a universal protein which is applicable to any scientist worldwide.
The Boster Bio Anti-CD31 /PECAM-1 (Endothelial cell marker) monoclonal antibody recognizes Human, Mouse, and Rat CD31. The three species share 68 percent amino acid sequence homology. This antibody is used for a wide variety of cell-based applications.
CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), is an extracellular glycoprotein that is expressed on the surface of platelets, monocytes, and some lymphocyte subsets. It plays several important roles in vascular biology, platelet function, thrombosis, and leukocyte migration through venular walls.
This antibody is used for various applications in cytometry, immunocytochemistry, and flow cytometry. This product is non-hazardous and stable for 24 months. It has been validated for a broad spectrum of applications. The Boster Quality Guarantee assures customers that all products will meet the specifications required by their research.
Besides being a key component in TEM, PECAM-1 also plays a role in regulating RhoA activity and inducing endothelial cell migration. It also plays an important role in apoptosis. In addition, it may target cells with high blood levels. The boster Bio Anti-CD31 / PECAM-1 (Endothelial Cell Marker) monoclonal antibody has been shown to inhibit the growth of tumor cells and improve overall patient survival.
The anti-CD31 / PECAM-1 monoclonal antibody is highly specific for endothelial cells and has been approved by the FDA for clinical use. It has demonstrated excellent results in experiments and can be used in human and mouse bone marrow transplantation. Interestingly, the anti-CD31 monoclonal antibody does not react with normal or malignant endothelial cells.
The anti-CD31 / PECAM-1 monoclonal antibody detects the constitutive expression of human endothelial cells. It also exhibits low cross-reactivity with other proteins and tissues. It also has high affinity for the target protein. Furthermore, this anti-CD31 / PECAM-1 (Endothelial Cell Marker) antibody binds endothelial cells and does not cross-react with other proteins.
PECAM-1 is a critical component of the endothelial barrier and could lead to a new treatment for diseases such as ARDS and sepsis. In mouse models that lack PECAM1, bone marrow cells that express PECAM1 restored the permeability barrier of blood vessels. This is a promising therapeutic option in many clinical trials.
This anti-CD31 antibody works in immunohistochemistry as well as in cancer diagnosis. It is able to distinguish a tumor's malignant angiogenic source by staining it with a CD31 monoclonal antibody. Although the results are preliminary, Boster Bio Anti-CD31 / PECAM-1 (Endothelial Cell Marker) monoclonal antibody has a good track record in the field.
Xenogen IVIS100 fluorescence imaging was also used to study human CD31. Mouse implanted with HUVEC (Human Umbilical Vessel Endothelial Cell Marker) and a control Matrigel implant were imaged by Xenogen IVIS100 fluorescence imaging system. The average fluorescence signal in the mouse body was increased over the first 5 min after injection. Approximately two hours later, the imaging probe was removed and the fluorescence signal returned to normal levels.
PMID: 10570958 by Krupnik V.E., et al. Functional and structural diversity of the human Dickkopf gene family.
PMID: 10652205 by Tsuji T., et al. A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines.