DHRS2 Antibodies

AND DHRS2 ELISA kits, DHRS2 Proteins

Many biological assays use antibodies to detect DHRS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DHRS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DHRS2 antibodies...

We validate the specificity of these antibodies to DHRS2 by testing them on tissues known to express DHRS2 positively and negatively. Browse below to find the DHRS2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DHRS2 Infographic by Boster Bio

All DHRS2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-DHRS2 Antibody

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A09810
100ul

DHRS2 (NM_182908) Human Over-expression Lysate

Human

$628
Cat # LS010202
100 µg

DHRS2 Overview

Facts about Dehydrogenase/reductase SDR family member 2, mitochondrial.

DHRS2 3D structure. Source: alphafold

Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2)

Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is exhibited in vitro with steroids, retinoids and sugars as substrates.

Attenuates MDM2-mediated p53/TP53 degradation, resulting in p53/TP53 stabilization and enhanced transcription activity, causing the accumulation of MDM2 and CDKN1A/p21. .

Gene Information

Human
Gene Name:	DHRS2
Uniprot:	Q13268
Entrez:	10202

Family

Belongs to:

short-chain dehydrogenases/reductases (SDR) family

Alternative Names

dehydrogenase/reductase (SDR family) member 2; dehydrogenase/reductase member 2; dehydrogenase/reductase SDR family member 2; Dicarbonyl reductase HEP27; EC 1.1.1.-; EC 1.1.1.184; HEP27; Protein D; SDR25C1; short chain dehydrogenase/reductase family 25C, member 1; short-chain alcohol dehydrogenase family member

Molecular Weight

Mass (kDA):
29.927 kDA

Genomic Context


Human

Location:	14q11.2
Sequence:	14; NC_000014.9 (23630115..23645639)

Tissue Specificity

Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes.

Subcellular Localizations

Mitochondrion matrix. Nucleus. A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.

Diseases

Malignant Neoplasms
Liver Carcinoma
Carcinoma
Neoplasms
Hepatoblastoma
Growth Arrest
Cell Invasion
Carcinoma, Endometrioid
Neoplasm Metastasis
Reperfusion Injury
Deficiency Of Butyryl-coa Dehydrogenase
Ischemia
Malignant Neoplasm Of Breast

Endometrial Neoplasms
Endometrial Polyp
Neoplasm Invasiveness
Osteosarcoma
Liver Neoplasms
Endometrial Carcinoma
Mammary Neoplasms

Interacting Proteins

APPBP2

Pathways

Localization
Cell Cycle
Response To Oxidative Stress
Cell Proliferation
Translation
Cell Differentiation
Dendritic Cell Differentiation

Protein Import

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DHRS2

References

PMID: 7556196 by Gabrielli F., et al. A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family.

PMID: 11997086 by Pellegrini S., et al. A human short-chain dehydrogenase/reductase gene: structure, chromosomal localization, tissue expression and subcellular localization of its product.