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Ddx4 Antibodies
AND Ddx4 ELISA kits, Ddx4 Proteins
Many biological assays use antibodies to detect Ddx4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ddx4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ddx4 antibodies...
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Ddx4 Infographic by Boster Bio
All Ddx4 Products
Product
Figures
Specificity
Applications
Price
Anti-DDX4/MVH Antibody Picoband®
1 Citations 1 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # PA1963
100 μg/vial
Cat # PA1963
100 μg/vial
Anti-DDX4/MVH Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02448
100 μg/vial
Cat # A02448
100 μg/vial
Mouse, Rat
IF, IHC, WB
$370
Cat # M02448-1
100 μg/vial
Cat # M02448-1
100 μg/vial
Ddx4 Overview
Facts about ATP-dependent RNA helicase DDX4.
ATP-dependent RNA helicase DDX4 (Ddx4)
ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is vital for the germline integrity (PubMed:20439430, PubMed:28633017). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and modulates the methylation and subsequent repression of transposons (PubMed:20439430, PubMed:28633017).
Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (PubMed:20439430, PubMed:28633017). Required for PIWIL2 slicing- triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs to piRNAs (PubMed:28633017).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Ddx4 |
| Uniprot: | Q61496 |
| Entrez: | 13206 |
Family
| Belongs to: |
|---|
| DEAD box helicase family |
Alternative Names
DDX4; DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; DEAD box protein 4; EC 3.6.1; EC 3.6.4.13; MGC111074; probable ATP-dependent RNA helicase DDX4; Vasa homolog; VASA; VASADEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4
Molecular Weight
Mass (kDA):
76.47 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 13 D2.2|13 63.87 cM |
| Sequence: | 13; |
Tissue Specificity
Testis-specific.
Diseases
- Infertility
- Azoospermia
- Male Infertility
- Neoplasms
- Malignant Neoplasms
- Growth Arrest
- Neoplasms, Germ Cell And Embryonal
- Immunologic Deficiency Syndromes
- Pituitary Diseases
- Oligospermia
- Spindle Cell Oncocytoma Of The Adenohypophysis
- Idiopathic Pneumonia Syndrome
Pathways
- Spermatogenesis
- Cell Development
- Germ Cell Development
- Cell Differentiation
- Localization
- Oogenesis
- Methylation
- Meiosis
- Translation
- Cell Proliferation
- Dna Methylation
- Pachytene
- Reverse Transcription
PTMs
- Methylation
- Demethylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ddx4
bosterbio.com/bosterbio-gene-info-cards/Ddx4
References
PMID: 7991615 by Fujiwara Y., et al. Isolation of a DEAD-family protein gene that encodes a murine homolog of Drosophila vasa and its specific expression in germ cell lineage.
PMID: 14736746 by Kuramochi-Miyagawa S., et al. Mili, a mammalian member of piwi family gene, is essential for spermatogenesis.
2 Publications of Boster Ddx4 Antibodies & ELISA Kits
- PubMed ID: 10.3390/ijms222212607, Single-Cell Atlas of Adult Testis in Protogynous Hermaphroditic Orange-Spotted G...
- PubMed ID: 10.1016/j.repbio.2020.100477, Evaluating differentiation potential of the human menstrual blood-derived stem c...
*More publications can be found for each product on its corresponding product page