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DDR2 Antibodies
AND DDR2 ELISA kits, DDR2 Proteins
Many biological assays use antibodies to detect DDR2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DDR2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DDR2 antibodies...
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DDR2 Infographic by Boster Bio
All DDR2 Products
Product
Figures
Specificity
Applications
Price
Anti-DDR2 Antibody Picoband®
16 Q&As
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01698-1
100 μg/vial
Cat # A01698-1
100 μg/vial
DDR2 Overview
Facts about Discoidin domain-containing receptor 2.
Discoidin domain-containing receptor 2 (DDR2)
Tyrosine kinase that acts as cell surface receptor for fibrillar collagen and modulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone growth.
Regulates osteoblast differentiation and chondrocyte maturation with a signaling pathway that involves MAP kinases and leads to the activation of this transcription factor RUNX2. Regulates remodeling of the extracellular matrix from up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion.
Gene Information
| Human | |
|---|---|
| Gene Name: | DDR2 |
| Uniprot: | Q16832 |
| Entrez: | 4921 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
CD167 antigen-like family member B; CD167b antigen; DDR2; Discoidin domain receptor 2; discoidin domain receptor family, member 2; discoidin domain receptor tyrosine kinase 2; discoidin domain-containing receptor 2; EC 2.7.10; EC 2.7.10.1; hydroxyaryl-protein kinase; migration-inducing gene 16 protein; neurotrophic tyrosine kinase receptor related 3; Neurotrophic tyrosine kinase, receptor-related 3; NTRKR3cell migration-inducing protein 20; Receptor protein-tyrosine kinase TKT; TKT; TKTMIG20a; Trk3; TYRO10; Tyro-10; Tyrosine-protein kinase TYRO10; tyrosylprotein kinase
Molecular Weight
Mass (kDA):
96.736 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.3 |
| Sequence: | 1; NC_000001.11 (162630863..162787405) |
Tissue Specificity
Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.
Diseases
- Neoplasms
- Malignant Neoplasms
- Tissue Adhesions
- Fibrosis
- Carcinoma
- Degenerative Polyarthritis
- Neoplasm Metastasis
- Hepatic Fibrosis
- Cell Invasion
- Arthritis
- Malignant Neoplasm Of Lung
- Dwarfism
- Rheumatoid Arthritis
Interacting Proteins
- COL11A2
- HSP90AB1
Pathways
- Cell Adhesion
- Cell Proliferation
- Pathogenesis
- Secretion
- Wound Healing
- Cell Migration
- Fibroblast Proliferation
- Cell Growth
- Cell Activation
- Osteoblast Differentiation
- Ossification
- Fibroblast Migration
- Spermatogenesis
PTMs
- Phosphorylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DDR2
bosterbio.com/bosterbio-gene-info-cards/DDR2
References
PMID: 8247548 by Karn T., et al. Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII- like domain.
PMID: 9659899 by Vogel W., et al. The discoidin domain receptor tyrosine kinases are activated by collagen.