Dynactin subunit 2 Antibodies

AND DCTN2 ELISA kits, Dynactin subunit 2 Proteins

Many biological assays use antibodies to detect Dynactin subunit 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dynactin subunit 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dynactin subunit 2 antibodies...

We validate the specificity of these antibodies to Dynactin subunit 2 by testing them on tissues known to express DCTN2 positively and negatively. Browse below to find the DCTN2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DCTN2 Infographic by Boster Bio

All DCTN2 Products

Product

Figures

Specificity

Applications

Price

Anti-p50 Dynamitin DCTN2 Antibody

7 Q&As

Human, Mouse, Rat

$360
Cat # A07698
100 µl

p50 Dynamitin Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$480
Cat # EKC1425
1 kit, containing one 96-well plate and all necessary reagents

Human Dynactin Subunit 2/DCTN2 Recombinant Protein

SDS-PAGE

$265
Cat # PROTQ13561
Starting from 10ug

Dynamitin (DCTN2) (NM_006400) Human Over-expression Lysate

Human

$628
Cat # LS010540
100 µg

DCTN2 Overview

Facts about Dynactin subunit 2.

DCTN2 3D structure. Source: alphafold

Dynactin subunit 2 (DCTN2)

Modulates cytoplasmic dynein binding to an organelle, and plays a part in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes.

May play a role in synapse formation during brain development. .

Gene Information

Human
Gene Name:	DCTN2
Uniprot:	Q13561
Entrez:	10540

Family

Belongs to:

dynactin subunit 2 family

Alternative Names

DCTN2; DCTN-50; DCTN5050 kD dynein-associated polypeptide; dynactin 2 (p50); dynactin complex 50 kD subunit; Dynactin complex 50 kDa subunit; Dynactin Subunit 2; dynactin subunit 2,50 kDa dynein-associated polypeptide; Dynamitin; p50 dynamitin; RBP50

Molecular Weight

Mass (kDA):
44.231 kDA

Genomic Context


Human

Location:	12q13.3
Sequence:	12; NC_000012.12 (57530050..57547331, complement)

Subcellular Localizations

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Peripheral membrane protein.

Diseases

Adenocarcinoma
Cns Disorder
Neurodegenerative Disorders
Colonic Neoplasms
Glioblastoma
Glioma
Nervous System Disorder
Polyploidy
Anaplastic Astrocytoma
Bone Neoplasms
Carcinogenesis
Osteosarcoma
Malignant Neoplasms

Low Grade Glioma
Neoplasms
Nervousness
Pilocytic Astrocytoma
Mammary Neoplasms
Rectal Neoplasms
Astrocytoma

Interacting Proteins

BLOC1S6
BORCS6
CCDC172
CEP44
DISC1

GADD45A
HAUS1
HTT
KIFC3
MAPRE3

PDCD6

Pathways

Transport
Mitosis

PTMs

Acetylation

Phosphoprotein

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DCTN2

References

PMID: 8647893 by Echeverri C.J., et al. Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis.

PMID: 10226031 by Berrueta L., et al. The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain.