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Alpha-crystallin B chain Antibodies
AND CRYAB ELISA kits, Alpha-crystallin B chain Proteins
Many biological assays use antibodies to detect Alpha-crystallin B chain, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Alpha-crystallin B chain in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Alpha-crystallin B chain antibodies...
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CRYAB Infographic by Boster Bio
All CRYAB Products
Product
Figures
Specificity
Applications
Price
Bovine, Mouse, Rat, Sheep, Porcine
IP, WB
$374
Cat # A03496
50 µg
Cat # A03496
50 µg
Human, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M03496
100 μl
Cat # M03496
100 μl
Human, Mouse, Rat
ELISA
$540
Cat # EKC2245
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2245
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2246
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2246
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A03496S19
100ul
Cat # A03496S19
100ul
Human, Monkey, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A03496S45
100ul
Cat # A03496S45
100ul
Human, Mouse, Rat
ELISA, IHC
$380
Cat # A03496S59
100ul
Cat # A03496S59
100ul
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03496-2
100 μg/vial
Cat # A03496-2
100 μg/vial
Human, Monkey, Mouse, Rat
Flow Cytometry, IP, IF, IHC, WB
$523
Cat # M03496-2
100 µl
Cat # M03496-2
100 µl
Human, Mouse, Rat
Flow Cytometry, IP, IHC, WB
$523
Cat # M03496-1
100 µl
Cat # M03496-1
100 µl
CRYAB Overview
Facts about Alpha-crystallin B chain.
Alpha-crystallin B chain (CRYAB)
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a broad selection of stress conditions.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | CRYAB |
| Uniprot: | P02511 |
| Entrez: | 1410 |
Family
| Belongs to: |
|---|
| small heat shock protein (HSP20) family |
Alternative Names
alpha B crystallin; alpha(B)-crystallin; AlphaB Crystallin; alpha-crystallin B chain; CRYA2; CRYA2alpha crystallin B chain; CRYAB; crystallin, alpha B; CTPP2; Heat shock protein beta-5; heat-shock 20 kD like-protein; HSPB5; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component
Molecular Weight
Mass (kDA):
20.159 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q23.1 |
| Sequence: | 11; NC_000011.10 (111908564..111923740, complement) |
Tissue Specificity
Lens as well as other tissues (PubMed:838078, PubMed:2387586). Expressed in myocardial tissue (PubMed:28493373).
Subcellular Localizations
Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (PubMed:19464326). Localizes at the Z-bands and the intercalated disk in cardiomyocytes (PubMed:28493373).
Diseases
- Cardiomyopathies
- Myopathy
- Cataract
- Neoplasms
- Hypertrophy
- Malignant Neoplasms
- Heart Failure
- Neurodegenerative Disorders
- Sclerosis
- Multiple Sclerosis
- Cardiac Hypertrophy
- Carcinoma
Interacting Proteins
- CRYAA
- CRYBA1
- CRYGC
- CRYGS
- HSPB1
- HSPB2
- HSPB8
- Tmem109
Pathways
- Pathogenesis
- Cell Death
- Autophagy
- Immune Response
- Cell Growth
- Cell Adhesion
- Aging
- Angiogenesis
- Secretion
- Cell Differentiation
- Methylation
- Regeneration
- Protein Folding
PTMs
- Phosphorylation
- Ubiquitination
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CRYAB
bosterbio.com/bosterbio-gene-info-cards/CRYAB
References
PMID: 838078 by Kramps J.A., et al. The primary structure of the B2 chain of human alpha-crystallin.
PMID: 2387586 by Dubin R.A., et al. Human alpha B-crystallin gene and preferential promoter function in lens.