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Carboxypeptidase E Antibodies
AND CPE ELISA kits, Carboxypeptidase E Proteins
Many biological assays use antibodies to detect Carboxypeptidase E, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Carboxypeptidase E in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Carboxypeptidase E antibodies...
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CPE Infographic by Boster Bio
All CPE Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$750
Cat # EK1887
96 wells/kit, with removable strips.
Cat # EK1887
96 wells/kit, with removable strips.
Mouse
ELISA
$750
Cat # EK1888
96 wells/kit, with removable strips.
Cat # EK1888
96 wells/kit, with removable strips.
Rat
ELISA
$750
Cat # EK1889
96 wells/kit, with removable strips.
Cat # EK1889
96 wells/kit, with removable strips.
CPE Overview
Facts about Carboxypeptidase E.
Carboxypeptidase E (CPE)
Removes residual C-terminal Arg or Lys staying after first endoprotease cleavage through prohormone processing. Processes proinsulin.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | CPE |
| Uniprot: | P16870 |
| Entrez: | 1363 |
Family
| Belongs to: |
|---|
| peptidase M14 family |
Alternative Names
Carboxypeptidase E; Carboxypeptidase H; CPE; CPH; CPH-1; EC 3.4.17; EC 3.4.17.10; Enkephalin convertase; Prohormone-processing carboxypeptidase
Molecular Weight
Mass (kDA):
53.151 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q32.3 |
| Sequence: | 4; NC_000004.12 (165379008..165498547) |
Tissue Specificity
Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas.
Subcellular Localizations
[Isoform 1]: Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions.; [Isoform 2]: Nucleus.
Diseases
- Cytopathogenic Effect, Viral
- Cytopathic Effect
- Dental Plaque
- Virus Diseases
- Infective Disorder
- Neoplasms
- Malignant Neoplasms
- Diarrhea
- Pituitary Diseases
- Hiv Infections
- Nervousness
- Obesity
Pathways
- Translation
- Secretion
- Viral Replication
- Transport
- Localization
- Pathogenesis
- Cell Death
- Oocyte Maturation
- Secretory Pathway
- Virulence
- Regulated Secretory Pathway
- Cell Cycle
- Tropism
PTMs
- Oxidation
- Cleavage
- Phosphorylation
- Amidation
- Reduction
- Nitration
- Dephosphorylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CPE
bosterbio.com/bosterbio-gene-info-cards/CPE
References
PMID: 2334405 by Manser E., et al. Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro.
PMID: 9662053 by Utsunomiya N., et al. Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity.