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1 Citations
Facts about Complement factor H.
Human | |
---|---|
Gene Name: | CFH |
Uniprot: | P08603 |
Entrez: | 3075 |
Belongs to: |
---|
No superfamily |
adrenomedullin binding protein; age-related maculopathy susceptibility 1; AHUS1; AMBP1; ARMD4; ARMS1; beta-1H; beta-1-H-globulin ; beta-1-H-globulin; CFH; CFHL3; Complement Factor H; factor H; factor H-like 1; FH; FHL1; H factor 1 (complement); H factor 1; H factor 2 (complement); HF; HF1; HF1ARMS1; HF2; HUS; HUSMGC88246
Mass (kDA):
139.096 kDA
Human | |
---|---|
Location: | 1q31.3 |
Sequence: | 1; NC_000001.11 (196651878..196747504) |
Expressed by the liver and secreted in plasma.
Secreted.
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Boster Bio's antibody has been developed to combat CD235a/glycophorin. The antibody was validated with known positive and negative samples to ensure high specificity and affinity. In addition, the antibody was validated in multiple platforms, including Western Blotting, Immunohistochemistry, and ELISA. This guide is an excellent guide for researchers, and it answers many questions. The information contained in the guide is the researcher with a practical guide and will help them improve their experiments to get best results.
The CFH marker is a new marker in the market for cardiovascular disease testing. It is used for risk assessment and diagnosis in acute coronary syndromes. The diagnosis of chest pain is made more straightforward by the troponin marker. Some companies have started offering tests for cardiac markers at the point of care because of this rapid growth. Companies like Biosite Diagnostics, which markets the CFH marker, along with other cardiac markers, are expanding rapidly. Biosite's sales increased by more than a third between 1999 and 2000, and reached $13.3 million in the world.
The CFH gene encodes a protein involved with the maintenance of homeostasis as well as the process of cell differentiation. There are numerous genetic variants in the gene which affect the binding capabilities of CFH and MDA-epitopes. These mutations are associated with a higher chance of developing age-related macular deterioration and other diseases. Many samples carry the CFH gene that includes brain, blood urine, peripheral blood.
CFH is found in lymphoid cells, fat cells, mesothelial cell, neuronal cells, and myeloid cells. Multiplexed FISH permits scientists to see the types of cells by looking at their transcript levels. Pericytes, cardiomyocytes and neuronal cells are stained with DCN and KCNJ8. Nuclei are stained using DAPI.
The CFH gene is a key regulator of the alternative complement pathway. CFH can be altered to block binding to MDA-decorated surfaces. Deletions in the gene for Complement Factor H cause a decrease in the regulation of complement by cells. This is one reason why this gene is involved in age-related macular and other complementopathies.
The CFH gene is a critical factor in the initiation of complement cascade. Variations in the gene can alter this process. These changes could cause changes in the physiologic evidence. The goal of this review is to give a brief overview of the CFH marker. The scientific community has a variety of applications for molecular biology techniques. DNA manipulation and investigation are tools that allow researchers to manipulate and analyze genetic material. Boster bio offers comprehensive technical information, blogs, and web-based digital tools. Furthermore, the company provides high-quality lysis buffers that will ensure the highest quality of results and lower cross-linking intensity.
PMID: 2963625 by Ripoche J., et al. The complete amino acid sequence of human complement factor H.
PMID: 2946589 by Schulz T.F., et al. Human complement factor H: isolation of cDNA clones and partial cDNA sequence of the 38-kDa tryptic fragment containing the binding site for C3b.
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