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CEACAM1 Antibodies
AND CEACAM1 ELISA kits, CEACAM1 Proteins
Many biological assays use antibodies to detect CEACAM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CEACAM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CEACAM1 antibodies...
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CEACAM1 Infographic by Boster Bio
All CEACAM1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK1361
96 wells/kit, with removable strips.
Cat # EK1361
96 wells/kit, with removable strips.
Anti-CEACAM1 (human) Monoclonal Antibody (GM8G5)
1 Citations 15 Q&As
Human
Flow Cytometry, IHC
$945
Cat # M00923-1
100µg
Cat # M00923-1
100µg
Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00923-3
100 μg/vial
Cat # A00923-3
100 μg/vial
CEACAM1 Overview
Facts about Carcinoembryonic antigen-related cell adhesion molecule 1.
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)
Isoform 1: Cell adhesion protein which mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin activity and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763).
Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of related receptors by dephosphorylation of the downstream effectors. Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730).
Gene Information
| Human | |
|---|---|
| Gene Name: | CEACAM1 |
| Uniprot: | P13688 |
| Entrez: | 634 |
Family
| Belongs to: |
|---|
| immunoglobulin superfamily |
Alternative Names
Nothing Found
Molecular Weight
Mass (kDA):
57.56 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.2 |
| Sequence: | 19; NC_000019.10 (42507306..42528482, complement) |
Tissue Specificity
Expressed in columnar epithelial cells of the colon (at protein level) (PubMed:10436421). The predominant forms expressed by T cells are those containing a long cytoplasmic domain (PubMed:18424730). Expressed in granulocytes and lymphocytes. Leukocytes only express isoforms 6 and isoform 1 (PubMed:11994468).
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Lateral cell membrane. Apical cell membrane. Basal cell membrane. Cell junction. Cell junction, adherens junction. Canalicular domain of hepatocyte plasma membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions. Found as dimer in the solution. Predominantly localized to the lateral cell membranes.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Cell membrane; Single-pass typ
Diseases
- Tissue Adhesions
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Hepatitis
- Murine Hepatitis
- Neoplasm Metastasis
- Tumor Angiogenesis
- Cell Invasion
- Melanoma
- Pathologic Neovascularization
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- CARTPT
- CEACAM6
- HAVCR2
Pathways
- Cell Adhesion
- Angiogenesis
- Cell-cell Adhesion
- Immune Response
- Pathogenesis
- Cell Proliferation
- Cell Growth
- Localization
- Secretion
- Cell Migration
- Phagocytosis
- Homophilic Cell Adhesion
- Glycosylation
PTMs
- Phosphorylation
- Glycosylation
- Cleavage
- Gpi Anchoring
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CEACAM1
bosterbio.com/bosterbio-gene-info-cards/CEACAM1
References
PMID: 2537311 by Barnett T.R., et al. Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family.
PMID: 2457922 by Hinoda Y., et al. Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen.
1 Publications of Boster CEACAM1 Antibodies & ELISA Kits
- PubMed ID: 26078764, Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Per...
*More publications can be found for each product on its corresponding product page