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Cyclin-dependent kinase 1 Antibodies
AND CDK1 ELISA kits, Cyclin-dependent kinase 1 Proteins
Many biological assays use antibodies to detect Cyclin-dependent kinase 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cyclin-dependent kinase 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cyclin-dependent kinase 1 antibodies...
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CDK1 Infographic by Boster Bio
All CDK1 Products
Product
Figures
Specificity
Applications
Price
Anti-CDK1 Antibody Picoband®
17 Citations 6 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # PB9533
100 μg/vial
Cat # PB9533
100 μg/vial
Anti-CDK1 Antibody (Monoclonal, A17)
12 Citations 4 Q&As
Chicken, Human, Mouse
IHC, WB
$370
Cat # MA1077
100 μg/vial
Cat # MA1077
100 μg/vial
Anti-PSTAIR Antibody (Monoclonal, PSTAIR)
9 Citations 15 Q&As
Human, Mouse, Rat
WB
$370
Cat # MA1087
100 μg/vial
Cat # MA1087
100 μg/vial
Anti-Cyclin-dependent kinase 1 CDK1 Antibody Picoband®
13 Citations 4 Q&As
Human
WB
$370
Cat # PA1544
100 μg/vial
Cat # PA1544
100 μg/vial
Anti-Phospho-cdc2 (Tyr15) CDK1 Antibody
5 Citations 15 Q&As
Human, Mouse, Xenopus
WB
$481
Cat # P00209
100 µl
Cat # P00209
100 µl
Anti-Phospho-Cdk1/2 (T14) Rabbit Monoclonal Antibody
4 Citations 5 Q&As
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # P00209-1
100 μl
Cat # P00209-1
100 μl
Anti-CDK1/Cdc2 Rabbit Monoclonal Antibody
3 Citations 16 Q&As
Human
IP, IF, IHC, ICC, WB
$370
Cat # M00209-2
100 μl
Cat # M00209-2
100 μl
Anti-CDK1/Cdc2 Rabbit Monoclonal Antibody
4 Citations 15 Q&As
Human, Mouse, Rat
WB
$370
Cat # M00209-3
100 μl
Cat # M00209-3
100 μl
Anti-CDK1/Cdc2 Rabbit Monoclonal Antibody
5 Citations 15 Q&As
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M00209-4
100 μl
Cat # M00209-4
100 μl
Anti-CDC2 (Ab-15) CDK1 Antibody
4 Citations 5 Q&As
Human, Mouse, Rat
IF, IHC, WB
$360
Cat # A00209
100 µl
Cat # A00209
100 µl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1104
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1104
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1107
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1107
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2063
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2063
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2368
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2368
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2369
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2369
1 kit, containing two 96-well plates and all necessary reagents
Anti-CDK1 Antibody Picoband® (monoclonal, 2G11)
7 Citations 5 Q&As
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M00209-6
100 μg/vial
Cat # M00209-6
100 μg/vial
CDK1 Overview
Facts about Cyclin-dependent kinase 1.
Cyclin-dependent kinase 1 (CDK1)
Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; boosts G2-M transition, and regulates G1 progress and G1-S transition through association with numerous interphase cyclins. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SIRT2 and RUNX2.
CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development.
Gene Information
| Human | |
|---|---|
| Gene Name: | CDK1 |
| Uniprot: | P06493 |
| Entrez: | 983 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
CDC2; CDC28A; CDC2MGC111195; CDK1; cell cycle controller CDC2; Cell division control protein 2 homolog; Cell division protein kinase 1; cyclin-dependent kinase 1; DKFZp686L20222; EC 2.7.11.22; EC 2.7.11.23; G1 to S and G2 to M; p34 protein kinase; P34CDC2
Molecular Weight
Mass (kDA):
34.095 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q21.2 |
| Sequence: | 10; NC_000010.11 (60778331..60794852) |
Tissue Specificity
Isoform 2 is found in breast cancer tissues.
Subcellular Localizations
Nucleus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Leukemia
- Retinoblastoma
- Malignant Neoplasm Of Breast
- Cell Transformation, Neoplastic
- Mammary Neoplasms
- Malignant Neoplasm Of Prostate
- Hyperplasia
- Malignant Paraganglionic Neoplasm
- Prostatic Neoplasms
Interacting Proteins
- ALYREF
- BIRC5
- CCNB1
- CDC25C
- CDC6
- CDKN1A
- CKS1B
- DLST
- EIF2AK2
- FOXO1
Pathways
- Cell Cycle
- Mitosis
- Cell Cycle Arrest
- S Phase
- Cell Proliferation
- Cell Division
- Cell Growth
- Localization
- Cell Death
- Dna Replication
- Anaphase
- Metaphase
- Interphase
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Ubiquitination
- Acetylation
- Methylation
- Reduction
- Sumoylation
Research Areas
- Breast Cancer
- Cancer
- Cell Cycle and Replication
- Core ESC-Like Genes
- Mitotic Regulators
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDK1
bosterbio.com/bosterbio-gene-info-cards/CDK1
References
PMID: 3553962 by Lee M.G., et al. Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2.
PMID: 9515786 by Ohta T., et al. T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21.
22 Publications of Boster Cyclin-dependent kinase 1 Antibodies & ELISA Kits
- PubMed ID: 10.3892/or.2017.5861, Pseudolaric acid B inhibits neuroglioma cell proliferation through DNA damage re...
- PubMed ID: 10.3892/or.2016.4742, A novel cell cycle blocker extracted from Stellera chamaejasme L. inhibits the ...
- PubMed ID: 10.1080/13880209.2021.1931354, Extract of Ganoderma sinensis spores induces cell cycle arrest of hepatoma cell ...
- PubMed ID: 10.1080/07357900701788130, Suppression of C-myc Expression Associates with Anti-Proliferation of Aloe-Emodi...
- PubMed ID: 10.1038/s41598-020-66018-5, Antitumor effect of a WEE1 inhibitor and potentiation of olaparib sensitivity by...
- PubMed ID: 33779025, Blakemore D,Vilaplana-Lopera N,Almaghrabi R,Gonzalez E,Moya M,Ward C,Murphy G,Ga...
- PubMed ID: 33292254, Wang C,Shao S,Deng L,Wang S,Zhang Y. LncRNA SNHG12 regulates the radiosensitivit...
- PubMed ID: 27109908, A novel cell cycle blocker extracted from Stellera chamaejasme L. inhibits the p...
- PubMed ID: 28229049, Human enterovirus 68 interferes with the host cell cycle to facilitate viral pro...
- PubMed ID: 30159255, Coxsackievirus A6 induces cell cycle arrest in G0/G1 phase for viral production
- PubMed ID: 29805667, Prostate cancer cell proliferation is suppressed by microRNA-3160-5p via targeti...
- PubMed ID: 27991546, APC/CCDC20 and APC/C play pivotal roles in the process of embryonic development ...
- PubMed ID: 26440151, Dietary NiCl2 causes G2/M cell cycle arrest in the broiler's kidney
- PubMed ID: 26385569, Glycyrrhizic Acid Prevents Sepsis-Induced Acute Lung Injury and Mortality in Rat...
- PubMed ID: 29636863, Zhang Q, Miao S, Li C, Cui K, Ge Q, Chen Z. Am J Transl Res. 2018 Mar 15;10(3):7...
- PubMed ID: 21288666, Ren Y, Wang Q, Shi L, Yue W, Zhang C, Lei F. Anim Reprod Sci. 2011 Feb;123(3-4):...
- PubMed ID: 23441067, Yang C, Yang J, Sun M, Yan J, Meng X, Ma T. Iubmb Life. 2013 May;65(5):435-44. D...
- PubMed ID: 25217394, Zeng Zj, Xiang Sg, Xue Ww, Li Hd, Ma N, Ren Zj, Xu Zj, Jiao Ch, Wang Cy, Hu Wx. ...
- PubMed ID: 19883635, Ye Z, Chen Z, Chen W, Xie J, Yang H, Lou Y, Yu Y. Chem Biol Interact. 2010 Jan 5...
- PubMed ID: 24789581, Zheng Q, Liu Y, Liu W, Ma F, Zhou Y, Chen M, Chang J, Wang Y, Yang G, He G. Mol ...
- PubMed ID: 20878477, Lin P, Fu J, Zhao B, Lin F, Zou H, Liu L, Zhu C, Wang H, Yu X. Mol Biol Rep. 201...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page