CD59 glycoprotein Antibodies

CD59 glycoprotein (CD59)

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 needed for complete formation of the osmolytic pore.

This inhibitor seems to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.

Gene Information

Human
Gene Name:	CD59
Uniprot:	P13987
Entrez:	966

Family

Belongs to:
No superfamily

Alternative Names

16.3A5; 1F5 antigen; 1F5; 20 kDa homologous restriction factor; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16; CD59 antigen; CD59 antigen, complement regulatory protein; CD59 glycoprotein; CD59 molecule, complement regulatory protein; CD59; EJ16; EJ30; EJ30, EL32 and G344); EL32; FLJ38134; FLJ92039; G344; HRF20; HRF-20; human leukocyte antigen MIC11; Ly-6-like protein; lymphocytic antigen CD59/MEM43; MACIF; MAC-inhibitory protein; MAC-IP; MEM43 antigen; MEM43; membrane attack complex (MAC) inhibition factor; Membrane attack complex inhibition factor; Membrane in

Molecular Weight

Mass (kDA):
14.177 kDA

Genomic Context

Human
Location:	11p13
Sequence:	11; NC_000011.10 (33703010..33736479, complement)

Subcellular Localizations

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Soluble form found in a number of tissues.

Diseases

• Paroxysmal Nocturnal Hemoglobinuria
• Hemoglobinuria
• Hemoglobinuria, Paroxysmal
• Hemolysis (disorder)
• Neoplasms
• Anemia
• Malignant Neoplasms
• Inflammation
• Aplastic Anemia
• Tissue Adhesions
• Leukemia
• Thrombosis
• Carcinoma

• Anemia, Hemolytic
• Lymphoma
• Autoimmune Reaction
• Malignant Paraganglionic Neoplasm
• Dysmyelopoietic Syndromes
• Pancytopenia
• Hematological Disease

Interacting Proteins

• TMED2

Pathways

• Complement Activation
• Pathogenesis
• Cytolysis
• Cell Activation
• Immune Response
• Localization
• Cell Death
• Secretion
• Glycosylation
• Cell Proliferation
• T Cell Activation
• Complement-dependent Cytotoxicity
• Inflammatory Response

• Endocytosis
• Transport
• Phagocytosis
• Cell Adhesion
• Cell Killing
• Coagulation
• Regeneration

PTMs

• Glycosylation
• Cleavage
• Gpi Anchoring
• Phosphorylation
• Acylation
• Biotinylation
• Deamination
• Ubiquitination

• Acetylation
• Dephosphorylation
• Oxidation
• Methylation
• Geranylgeranylation
• Ribosylation
• Reduction
• Deglycosylation

Research Areas

• Cell Biology
• Cellular Markers
• Immunology
• Signal Transduction
• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD59

Boster Bio - Best Uses Of The CD59 Marker

This article outlines the Boster Bio's best uses and tips for getting the most from your results. You'll also find troubleshooting guides and optimization tips. This article applies to scientists around the world. You may be wondering whether you should use the Boster Bio anti-Desmin antibody or an alternative antibody. Read on to learn more. It's time to get your Boster Bio set up and running!

Boster Bio optimization tips

Every researcher encounters some type of error in their experiments. Common problems are high background, unexpected staining, and weak fluorescence signals. By using proper controls, most of these problems can be eliminated. Troubleshooting guides from Boster Bio are a great source of information for optimizing experiments. In addition, you can follow these tips to optimize your experiment. You can also get Boster's help for any questions you may have.

Boster Bio troubleshooting guides

Using ELISA to analyze cell proliferation is a common lab practice, but there are specific tips and tricks to use to optimize your experiments. These guides offer detailed step-by-step guides that serve as primers and quick reference guides for the process. The binding of antibodies to surface antigens can stimulate cells or alter the expression of intracellular signalling proteins. The use of Saponin or Methanol, or both, is compatible with flow cytometry. The protocols also provide optimization tips and troubleshooting advice.

In addition to troubleshooting tips and best practices, the guide also contains step-by-step IHC protocols, recommended reagents, and a step-by-step illustrated workflow. Optimal sample preparation is essential for obtaining high-quality staining results. The guide explains proper sample preparation, including antigen retrieval, fixation, embedding, and sample processing techniques. It also covers the optimal procedures for different types of tissue preservation. The right preparation of tissues is vital for achieving quality staining results.

Boster Bio anti-Desmin antibody

The anti-Desmin antibody from Boster Bio uses the CD59 marker for its validation. This antibody has been validated on multiple platforms with known positive and negative samples to assure high affinity and specificity. In addition to validation, Boster also rewards the first reviewers of its products with product credits. Regardless of the size of your institution, this company rewards scientists all over the world for their valuable input.

The anti-Desmin antibody from Boster Bio is a PE-conjugated monoclonal antibody that reacts with Human, Mouse, and rat. It is recommended to store it at 4°C and protect it from prolonged exposure to light. It is not recommended to freeze this antibody for longer than two weeks. The antibody can be used on both human and mouse cells.