Ccr2 Antibodies

C-C chemokine receptor type 2 (Ccr2)

Receptor for the CCL2, CCL7 and CCL12 chemokines (PubMed:8996246).

Receptor for the beta-defensin DEFB106A/DEFB106B (By similarity).

Transduces a signal by increasing intracellular calcium ion levels (PubMed:8996246). Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (By similarity).

Gene Information

Mouse
Gene Name:	Ccr2
Uniprot:	P51683
Entrez:	12772

Family

Belongs to:
G-protein coupled receptor 1 family

Alternative Names

C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CC-CKR-2CKR2B; CCR2; CCR-2; CCR2A; CCR2B; CD192 antigen; CD192; chemokine (C-C motif) receptor 2; CKR2; CKR2A; CMKBR2; CMKBR2MGC111760; FLJ78302; MCP-1 receptor; MCP-1-R; MCP-1-RMGC103828; MGC168006; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor

Molecular Weight

Mass (kDA):
42.783 kDA

Genomic Context

Mouse
Location:	9 F4|9 75.05 cM
Sequence:	9;

Tissue Specificity

Detected in monocyte/macrophage cell lines, but not in nonhematopoietic cell lines.

Diseases

• Inflammation
• Cholangiocarcinoma
• Hiv Infections
• Atherosclerosis
• Immunologic Deficiency Syndromes
• Acquired Immunodeficiency Syndrome
• Autoimmune Reaction
• Neoplasms
• Tissue Adhesions
• Malignant Neoplasms
• Fibrosis
• Inflammatory Response

• Nervousness
• Sclerosis
• Multiple Sclerosis
• Arthritis
• Diabetes Mellitus
• Kidney Diseases
• Infective Disorder

Pathways

• Chemotaxis
• Pathogenesis
• Immune Response
• Secretion
• Cell Migration
• Inflammatory Response
• Angiogenesis
• Localization
• Monocyte Chemotaxis
• Cell Proliferation
• Leukocyte Migration
• Regeneration
• Hypersensitivity

• Cytokine Production
• Cell Activation
• Cell Death
• Cell Adhesion
• Phagocytosis
• Chemokine Production
• Innate Immune Response

PTMs

• Phosphorylation
• Cleavage
• Methylation
• Biotinylation
• Reduction
• Glycosylation

• Acetylation
• Oxidation
• Nitration
• Phosphorothioation
• Acylation
• Palmitoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ccr2

Boster Bio Anti-Macrosialin CD68 Antibody

If you are looking for an antibody, you may be wondering what Boster Bio Anti-Macrosialin CD68 Antibody is and what it can do for you. The company started in 1993 and specializes in antibody manufacturing. It has recently expanded its offerings to include PCR-related molecular biology products. In addition to offering quality antibodies, Boster Bio provides a wide range of services for scientists. Technical resources and free technical support are also provided to customers.

Boster Bio Anti-Macrosialin CD68 Antibody

The anti-Macrosialin CD68 antibody is a 110 kD transmembrane glycoprotein highly expressed in human monocytes and tissue macrophages. It belongs to the family of mucin-like molecules and has a genome-wide position of 17p13.1. It is a very useful marker of macrophage lineage and helps differentiate various diseases, even though their cellular appearance is similar.