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G1/S-specific cyclin-D2 Antibodies
AND CCND2 ELISA kits, G1/S-specific cyclin-D2 Proteins
Many biological assays use antibodies to detect G1/S-specific cyclin-D2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with G1/S-specific cyclin-D2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop G1/S-specific cyclin-D2 antibodies...
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CCND2 Infographic by Boster Bio
All CCND2 Products
Product
Figures
Specificity
Applications
Price
Anti-Cyclin D2 Ccnd2 Antibody (Monoclonal, DCS-3)
2 Citations 3 Q&As
Human, Mouse
ICC, WB
$370
Cat # MA1034
100 μg/vial
Cat # MA1034
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1154
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1154
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A01079T280
100ul
Cat # A01079T280
100ul
CCND2 Overview
Facts about G1/S-specific cyclin-D2.
G1/S-specific cyclin-D2 (CCND2)
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complicated and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.
Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
Gene Information
| Human | |
|---|---|
| Gene Name: | CCND2 |
| Uniprot: | P30279 |
| Entrez: | 894 |
Family
| Belongs to: |
|---|
| cyclin family |
Alternative Names
CCND2; Cyclin D2; G1/S-specific cyclin D2; G1/S-specific cyclin-D2; KIAK0002; MGC102758; Vin1
Molecular Weight
Mass (kDA):
33.067 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12p13.32 |
| Sequence: | 12; NC_000012.12 (4273762..4305353) |
Subcellular Localizations
Nucleus. Cytoplasm. Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.; [Isoform 2]: Cytoplasm.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Retinoblastoma
- Cell Transformation, Neoplastic
- Leukemia
- Lymphoma
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Multiple Myeloma
- Carcinogenesis
- B-cell Lymphomas
Interacting Proteins
- CDK4
- CDK5
- CDKN1A
- CDKN1B
Pathways
- Cell Cycle
- Cell Proliferation
- Methylation
- S Phase
- G1 Phase
- Cell Growth
- Cell Cycle Arrest
- Pathogenesis
- Cell Death
- Cell Division
- Localization
- Cell Differentiation
- Dna Methylation
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Demethylation
- Dephosphorylation
Research Areas
- Cell Cycle and Replication
- Core ESC-Like Genes
- Ovarian Carcinoma Cell Markers
- Stem Cell Markers
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCND2
bosterbio.com/bosterbio-gene-info-cards/CCND2
References
PMID: 1386336 by Xiong Y., et al. Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins.
PMID: 8455931 by Palmero I., et al. Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines.
2 Publications of Boster G1/S-specific cyclin-D2 Antibodies & ELISA Kits
- PubMed ID: 27855694, CD274 promotes cell cycle entry of leukemia-initiating cells through JNK/Cyclin ...
- PubMed ID: 24853807, Sun L, Carr Al, Li P, Lee J, Mcgregor M, Li L. Biochem Biophys Res Commun. 2014 ...
*More publications can be found for each product on its corresponding product page