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- Table of Contents
Facts about Carbonic anhydrase 9.
May be involved in the control of cell proliferation and transformation. Appears to be a publication specific biomarker for a cervical neoplasia.
Human | |
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Gene Name: | CA9 |
Uniprot: | Q16790 |
Entrez: | 768 |
Belongs to: |
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alpha-carbonic anhydrase family |
CA9; CAIX; CA-IX; Carbonate dehydratase IX; carbonic anhydrase 9; Carbonic Anhydrase IX; carbonic dehydratase; EC 4.2.1.1; G250; Membrane antigen MN; MN; P54/58N; PMW1; RCC; RCC-associated antigen G250; RCC-associated protein G250; Renal cell carcinoma-associated antigen G250
Mass (kDA):
49.698 kDA
Human | |
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Location: | 9p13.3 |
Sequence: | 9; NC_000009.12 (35673809..35681159) |
Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa.
Nucleus. Nucleus, nucleolus. Cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Found on the surface microvilli and in the nucleus, particularly in nucleolus.
PMID: 8084592 by Pastorek J., et al. Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix- loop-helix DNA binding segment.
PMID: 10709109 by Grabmaier K., et al. Molecular cloning and immunogenicity of renal cell carcinoma- associated antigen G250.