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Cytochrome P450 4F2 Antibodies
AND CYP4F2 ELISA kits, Cytochrome P450 4F2 Proteins
Many biological assays use antibodies to detect Cytochrome P450 4F2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 4F2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 4F2 antibodies...
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CYP4F2 Overview
Facts about Cytochrome P450 4F2.
Cytochrome P450 4F2 (CYP4F2)
Omega-hydroxylase that oxidizes a number of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a crucial role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2.
Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE), potentially influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070).
Gene Information
| Human | |
|---|---|
| Gene Name: | CYP4F2 |
| Uniprot: | P78329 |
| Entrez: | 8529 |
Family
| Belongs to: |
|---|
| cytochrome P450 family |
Alternative Names
CPF2; CYPIVF2; Cytochrome P450 4F2; cytochrome P450, family 4, subfamily F, polypeptide 2; cytochrome P450, subfamily IVF, polypeptide 2; Cytochrome P450-LTB-omega; EC 1.14.13.30; leukotriene B4 omega-hydroxylase; Leukotriene-B(4) 20-monooxygenase 1; leukotriene-B(4) omega-hydroxylase 1; leukotriene-B4 20-monooxygenase
Molecular Weight
Mass (kDA):
59.853 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.12 |
| Sequence: | 19; NC_000019.10 (15878023..15898074, complement) |
Tissue Specificity
Liver. Also present in kidney: specifically expressed in the S2 and S3 segments of proximal tubules in cortex and outer medulla (PubMed:10660572).
Subcellular Localizations
Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Diseases
- Hypertensive Disease
- Cholangiocarcinoma
- Thromboembolism
- Hemorrhage
- Inflammation
- Cerebrovascular Accident
- Malignant Neoplasms
- Neoplasms
- Infarction
- Myocardial Infarction
- Atrial Fibrillation
- Dysequilibrium Syndrome
- Liver Carcinoma
Interacting Proteins
- NCK1
Pathways
- Translation
- Localization
- Pathogenesis
- Transport
- Excretion
- Regulation Of Blood Pressure
- Cell Proliferation
- Response To Vitamin
- Inflammatory Response
- Lipid Homeostasis
- Response To Vitamin K
- Protein Phosphorylation
- Hepatocyte Differentiation
PTMs
- Hydroxylation
- Oxidation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP4F2
bosterbio.com/bosterbio-gene-info-cards/CYP4F2
References
PMID: 8026587 by Kikuta Y., et al. Cloning and expression of a novel form of leukotriene B4 omega- hydroxylase from human liver.
PMID: 10492403 by Kikuta Y., et al. Expression and molecular cloning of human liver leukotriene B4 omega- hydroxylase (CYP4F2) gene.