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- Table of Contents
Facts about Cytoplasmic FMR1-interacting protein 2.
As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). .
Human | |
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Gene Name: | CYFIP2 |
Uniprot: | Q96F07 |
Entrez: | 26999 |
Belongs to: |
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CYFIP family |
Cytoplasmic FMR1-interacting protein 2
Mass (kDA):
148.399 kDA
Human | |
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Location: | 5q33.3 |
Sequence: | 5; NC_000005.10 (157266091..157395594) |
Expressed in T-cells. Increased expression is observed in CD4(+) T-lymphocytes from patients with multiple sclerosis (at protein level).
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Highly expressed in the perinuclear regionand enriched in synaptosomes (By similarity). Treatment with leptomycin-B triggers translocation to the nucleus (PubMed:17245118).
PMID: 10449408 by Saller E., et al. Increased apoptosis induction by 121F mutant p53.
PMID: 15048733 by Mayne M., et al. CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion.