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CXCR4 Antibodies
AND CXCR4 ELISA kits, CXCR4 Proteins
Many biological assays use antibodies to detect CXCR4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CXCR4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CXCR4 antibodies...
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CXCR4 Infographic by Boster Bio
All CXCR4 Products
Product
Figures
Specificity
Applications
Price
Anti-CXCR4 Antibody Picoband®
28 Citations 16 Q&As
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1237
100 μg/vial
Cat # PA1237
100 μg/vial
Anti-CXCR4 Monoclonal Antibody
5 Citations 16 Q&As
Human, Mouse
IF, IHC, ICC, WB
$370
Cat # M00031
100 μl
Cat # M00031
100 μl
Anti-CXCR4 Antibody Picoband®
3 Citations 16 Q&As
Human, Mouse, Rat
ELISA, WB
$370
Cat # A00031-2
100 μg/vial
Cat # A00031-2
100 μg/vial
Human, Mouse, Rat
ELISA
$540
Cat # EKC2239
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2239
1 kit, containing two 96-well plates and all necessary reagents
Anti-CXCR4 Antibody
3 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC-P, ICC, WB
$449
Cat # A00031-1
0.1 mg
Cat # A00031-1
0.1 mg
Human, Monkey, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00031S339-1
100ul
Cat # A00031S339-1
100ul
Anti-CXCR4 Antibody Picoband®
3 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00031-4
100 μg/vial
Cat # A00031-4
100 μg/vial
CXCR4 Overview
Facts about C-X-C chemokine receptor type 4.
C-X-C chemokine receptor type 4 (CXCR4)
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by raising intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:28978524, PubMed:18799424, PubMed:24912431). Involved in the AKT signaling cascade (PubMed:24912431).
Plays a role in regulation of cell migration, e.g.
Gene Information
| Human | |
|---|---|
| Gene Name: | CXCR4 |
| Uniprot: | P61073 |
| Entrez: | 7852 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
CD184; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CXCR4; CXC-R4; CXCR-4; D2S201E; D2S201ESDF-1 receptor; FB22; Fusin; HM89; HM89NPYRL; HSY3RR; LAP3; LAP-3; LCR1; LESTR; LESTRCD184 antigen; Leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; NPY3R; NPY3RWHIM; NPYR; NPYRL; NPYY3R; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; Stromal cell-derived factor 1 receptor;
Molecular Weight
Mass (kDA):
39.746 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q22.1 |
| Sequence: | 2; NC_000002.12 (136114349..136118149, complement) |
Tissue Specificity
Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome. In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC).
Diseases
- Hiv Infections
- Immunologic Deficiency Syndromes
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Tissue Adhesions
- Acquired Immunodeficiency Syndrome
- Inflammation
- Cell Invasion
- Tumor Angiogenesis
- Carcinoma
- Malignant Neoplasm Of Breast
Interacting Proteins
- ACKR3
- ADRA1A
- ADRA1B
- ADRA1D
- AVPR1A
- CCR5
- CD164
- CD74
- CXCR3
- CXCR5
Pathways
- Chemotaxis
- Cell Migration
- Pathogenesis
- Angiogenesis
- Tropism
- Cell Proliferation
- Secretion
- Localization
- Regeneration
- Immune Response
- Viral Replication
- Cell Adhesion
- Membrane Fusion
PTMs
- Phosphorylation
- Cleavage
- Glycosylation
- Methylation
- Ubiquitination
- Acetylation
- Demethylation
- Dephosphorylation
- Biotinylation
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CXCR4
bosterbio.com/bosterbio-gene-info-cards/CXCR4
References
PMID: 8329116 by Herzog H., et al. Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: lack of NPY binding and activation.
PMID: 8234909 by Jazin E.E., et al. A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells.
31 Publications of Boster CXCR4 Antibodies & ELISA Kits
- PubMed ID: 10.4049/jimmunol.1402097, Macrophage Migration Inhibitory Factor–CXCR4 Is the Dominant Chemotactic Axis ...
- PubMed ID: 10.3892/mmr.2018.9444, CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑...
- PubMed ID: 10.3892/etm.2021.10634, CXCR4 protects bone marrow‑derived endothelial progenitor cells against hypoxi...
- PubMed ID: 10.3892/etm.2019.7658, Forkhead box P3 gene silencing inhibits the expression of chemokines and chemoki...
- PubMed ID: 10.3760/cma.j.issn.0366-6999.20123471, Effect of CO2 pneumoperitoneum on the expression of the chemokine receptors CXCR...
- PubMed ID: 10.3748/wjg.v17.i19.2389, CXCR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma
- PubMed ID: 10.1186/1756-9966-27-62, Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineura...
- PubMed ID: 10.1177/1535370213477598, Overexpression of CXCR4 in tracheal epithelial cells promotes their proliferatio...
- PubMed ID: 10.1139/bcb-2017-0074, The CXCL12–CXCR4 axis promotes migration, invasiveness, and EMT in human papil...
- PubMed ID: 10.1021/acsami.8b08668, Demineralized Bone Scaffolds with Tunable Matrix Stiffness for Efficient Bone In...
- PubMed ID: 10.1016/j.jconrel.2021.11.029, Preferential siRNA delivery to injured kidneys for combination treatment of acut...
- PubMed ID: 10.1016/j.cellbi.2009.01.012, Oxidative preconditioning promotes bone marrow mesenchymal stem cells migration ...
- PubMed ID: 10.1016/j.brainres.2007.11.068, SDF-1α/CXCR4-mediated migration of systemically transplanted bone marrow stroma...
- PubMed ID: 10.1007/s11596-009-0406-8, Effects of stromal-derived factor 1 preconditioning on apoptosis of rat bone mes...
- PubMed ID: 32119183, Liu Y,Feng Q,Miao J,Wu Q,Zhou S,Shen W,Feng Y,Hou FF,Liu Y,Zhou L.C-X-C motif ch...
- PubMed ID: 33413641, Gao W,Yang X,Du J,Wang H,Zhong H,Jiang J,Yang C.Glucocorticoid guides mobilizati...
- PubMed ID: 25712213, Macrophage migration inhibitory factor%u2013CXCR4 is the dominant chemotactic ax...
- PubMed ID: 30221695, CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4%u2...
- PubMed ID: 18983683, Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineura...
- PubMed ID: 25471741, Blockade of CXCL12/CXCR4 signaling inhibits intrahepatic cholangiocarcinoma prog...
- PubMed ID: 24912495, Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF-1? expressio...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page