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CXCR3 Antibodies
AND CXCR3 ELISA kits, CXCR3 Proteins
Many biological assays use antibodies to detect CXCR3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CXCR3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CXCR3 antibodies...
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CXCR3 Infographic by Boster Bio
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CXCR3 Overview
Facts about C-X-C chemokine receptor type 3.
C-X-C chemokine receptor type 3 (CXCR3)
Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21.
Probably boosts cell chemotaxis response. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CXCR3 |
| Uniprot: | P49682 |
| Entrez: | 2833 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
CD183 antigen; CD183; chemokine (C-X-C motif) receptor 3; chemokine (C-X-C) receptor 3; CKR-L2IP-10 receptor; CMKAR3; C-X-C chemokine receptor type 3; CXCR3; CXC-R3; CXCR-3; G protein-coupled receptor 9CD182; GPR9; GPR9Mig-R; Interferon-inducible protein 10 receptor; IP10 receptor; IP10-R; Mig receptor; MigR
Molecular Weight
Mass (kDA):
40.66 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq13.1 |
| Sequence: | X; NC_000023.11 (71615913..71618515, complement) |
Tissue Specificity
Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).
Subcellular Localizations
[Isoform 1]: Cell membrane; Multi-pass membrane protein.; [Isoform 2]: Cell membrane; Multi-pass membrane protein.
Diseases
- Inflammation
- Neoplasms
- Autoimmune Reaction
- Malignant Neoplasms
- Tissue Adhesions
- Sclerosis
- Cholangiocarcinoma
- Multiple Sclerosis
- Nervousness
- Arthritis
- Hepatitis
- Virus Diseases
- Autoimmune Diseases
Interacting Proteins
- CXCR4
- FATE1
Pathways
- Pathogenesis
- Chemotaxis
- Immune Response
- Secretion
- Cell Migration
- Angiogenesis
- Cell Proliferation
- Localization
- Inflammatory Response
- Cytokine Production
- Cell Activation
- T Cell Activation
- Chemokine Production
PTMs
- Phosphorylation
- Cleavage
- Methylation
- Demethylation
- Acetylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CXCR3
bosterbio.com/bosterbio-gene-info-cards/CXCR3
References
PMID: 9064356 by Loetscher M., et al. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.
PMID: 12782716 by Lasagni L., et al. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4.
7 Publications of Boster CXCR3 Antibodies & ELISA Kits
- PubMed ID: 10.3389/fonc.2021.629350, CXCL10 Produced by HPV-Positive Cervical Cancer Cells Stimulates Exosomal PDL1 E...
- PubMed ID: 10.1016/j.biopha.2019.109735, Bu-Shen-Fang-Chuan formula attenuates T-lymphocytes recruitment in the lung of r...
- PubMed ID: 10.1007/s12264-020-00608-1, CXCL10/CXCR3 Signaling in the DRG Exacerbates Neuropathic Pain in Mice
- PubMed ID: 33469355, Ju YY,Jiang M,Xu F,Wang D,Ding B,Ma LJ,Wu H.CXCL10 and CXCR3 in the Trigeminal G...
- PubMed ID: 31864210, Li Q,Sun J,Cao Y,Liu B,Li L,Mohammadtursun N,Zhang H,Dong J,Wu J.Bu-Shen-Fang-Ch...
- PubMed ID: 26823797, Impact of chemokine receptor CXCR3 on tumor-infiltrating lymphocyte recruitment ...
- PubMed ID: 26883105, An alternatively spliced variant of CXCR3 mediates the metastasis of CD133+ live...
*More publications can be found for each product on its corresponding product page