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Cullin-3 Antibodies
AND CUL3 ELISA kits, Cullin-3 Proteins
Many biological assays use antibodies to detect Cullin-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cullin-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cullin-3 antibodies...
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CUL3 Infographic by Boster Bio
All CUL3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, WB
$370
Cat # M00747
100 μl
Cat # M00747
100 μl
CUL3 Overview
Facts about Cullin-3.
Cullin-3 (CUL3)
Core component of numerous cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
The E3 ubiquitin- protein ligase activity of this complex is dependent upon the neddylation of the cullin subunit and is inhibited by the association of this deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex is based upon the BTB domain-containing protein as the substrate recognition component.
Gene Information
| Human | |
|---|---|
| Gene Name: | CUL3 |
| Uniprot: | Q13618 |
| Entrez: | 8452 |
Family
| Belongs to: |
|---|
| cullin family |
Alternative Names
CUL-3; cullin 3; cullin-3; KIAA0617
Molecular Weight
Mass (kDA):
88.93 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q36.2 |
| Sequence: | 2; NC_000002.12 (224470150..224585397, complement) |
Tissue Specificity
Brain, spermatozoa, and testis (at protein level). Widely expressed.
Subcellular Localizations
Nucleus. Golgi apparatus. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Detected along the length of the sperm flagellum and in the cytoplasm of the germ cells (PubMed:28395323). Predominantly found in the nucleus in interphase cells, found at the centrosome at late G2 or prophase, starts accumulating at the spindle poles in prometaphase and stays on the spindle poles and the mitotic spindle at metaphase (PubMed:23213400).
Diseases
- Malignant Neoplasms
- Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Lung
- Epilepsy
- Tumor Angiogenesis
- Hypertensive Disease
- Non-small Cell Lung Carcinoma
- Neurodegenerative Disorders
- Pseudohypoaldosteronism
Interacting Proteins
- ABTB1
- CAND1
- CASP8
- CCDC22
- DCUN1D3
- HSP90AB1
- KCTD13
- KCTD6
- KCTD9
- KLHL12
Pathways
- Proteolysis
- Cell Cycle
- Mitosis
- Conjugation
- Localization
- Cell Death
- Cell Proliferation
- Anaphase
- Rna Interference
- Nuclear Export
- Cytokinesis
- Eye Development
- Transport
PTMs
- Ubiquitination
- Phosphorylation
- Acetylation
- Oxidation
Research Areas
- Apoptosis
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CUL3
bosterbio.com/bosterbio-gene-info-cards/CUL3
References
PMID: 9733711 by Du M., et al. Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of cullin/Cdc53 family.
PMID: 9663463 by Michel J.J., et al. Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A.