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- Table of Contents
Facts about Cysteine and glycine-rich protein 3.
Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and might promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the business of cytosolic structures in cardiomyocytes.
Human | |
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Gene Name: | CSRP3 |
Uniprot: | P50461 |
Entrez: | 8048 |
Belongs to: |
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No superfamily |
Cardiac LIM protein; CLPMGC14488; CMD1Mcardiac LIM domain protein; CMH12; CRP3cysteine and glycine-rich protein 3; cysteine and glycine-rich protein 3 (cardiac LIM protein); Cysteine-rich protein 3; LIM domain only 4; LIM domain protein, cardiac; LMO4; MLPMGC61993; Muscle LIM protein
Mass (kDA):
20.969 kDA
Human | |
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Location: | 11p15.1 |
Sequence: | 11; NC_000011.10 (19182030..19201983, complement) |
Cardiac and slow-twitch skeletal muscles. Isoform 2 is expressed in striated muscle. Isoform 2 is specifically expressed at higher levels in patients with neuromuscular diseases, such as limb-girdle muscular dystrophy 2A (LGMD2A), Duchenne muscular dystrophy (DMD) and dermatomyositis (PubMed:24860983).
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm, myofibril, sarcomere. Nucleocytoplasmic shuttling protein. Mainly cytoplasmic. In the Z line, found associated with GLRX3 (By similarity).; [Isoform 2]: Cytoplasm, myofibril, sarcomere, Z line.
PMID: 7490106 by Fung Y.W., et al. Mapping of a human LIM protein (CLP) to human chromosome 11p15.1 by fluorescence in situ hybridization.
PMID: 24860983 by Vafiadaki E., et al. Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation.