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- Table of Contents
Facts about Chondroitin sulfate proteoglycan 4.
Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity.
Human | |
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Gene Name: | CSPG4 |
Uniprot: | Q6UVK1 |
Entrez: | 1464 |
Belongs to: |
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No superfamily |
AN2; chondroitin sulfate proteoglycan 4 (melanoma-associated); chondroitin sulfate proteoglycan 4; CSPG4; EC 3.6.3; HMW-MAA; MCSP; MCSPChondroitin sulfate proteoglycan NG2; MCSPG; MCSPGMelanoma chondroitin sulfate proteoglycan; MEL-CSPG; MSK16Melanoma-associated chondroitin sulfate proteoglycan; NG2; NG2EC 2.7.8
Mass (kDA):
250.537 kDA
Human | |
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Location: | 15q24.2 |
Sequence: | 15; NC_000015.10 (75674322..75712848, complement) |
Detected only in malignant melanoma cells.
Cell membrane; Single-pass type I membrane protein; Extracellular side. Apical cell membrane; Single-pass type I membrane protein; Extracellular side. Cell projection, lamellipodium membrane; Single-pass type I membrane protein; Extracellular side. Cell surface. Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity).
PMID: 8790396 by Pluschke G., et al. Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan.
PMID: 15210734 by Yang J., et al. Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms.