Cryptochrome-1 Antibodies

Cryptochrome-1 (CRY1)

Transcriptional repressor which forms a core part of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes throughout the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in behavior and metabolism.

It's derived from the Latin roots'circa' (about) and'diem' (day) and acts as an important regulator of a wide variety of physiological functions such as metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two significant components: the central clock, living in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks which are found in virtually every tissue and organ system.

Gene Information

Human
Gene Name:	CRY1
Uniprot:	Q16526
Entrez:	1407

Family

Belongs to:
DNA photolyase class-1 family

Alternative Names

CRY1; cryptochrome 1 (photolyase-like); Cryptochrome I; PHLL1; PHLL1cryptochrome-1; photolyase-like cryptochrome 1

Molecular Weight

Mass (kDA):
66.395 kDA

Genomic Context

Human
Location:	12q23.3
Sequence:	12; NC_000012.12 (106991364..107093872, complement)

Subcellular Localizations

Cytoplasm. Nucleus. Translocated to the nucleus through interaction with other clock proteins such as PER2 or ARNTL/BMAL1.

Diseases

• Malignant Neoplasms
• Neoplasms
• Obesity
• Pituitary Diseases
• Diabetes Mellitus
• Diabetes Mellitus, Non-insulin-dependent
• Cell Transformation, Neoplastic
• Malignant Neoplasm Of Breast
• Leukemia
• Bipolar Disorder
• Jet Lag Syndrome
• Malnutrition

• Blind Vision
• Colorectal Cancer
• Hypertensive Disease
• Inflammation
• Nervousness
• Insulin Resistance
• Mood Disorders

Pathways

• Circadian Rhythm
• Photomorphogenesis
• Phototropism
• Localization
• Secretion
• Dna Repair
• Response To Blue Light
• De-etiolation
• Transport
• Cell Cycle
• Photosynthesis
• Germination
• Pathogenesis

• Methylation
• Chloroplast Relocation
• Auxin Transport
• Sporulation
• Translation
• Bioluminescence
• Phototransduction

PTMs

• Phosphorylation
• Methylation
• Acetylation
• Reduction
• Deacetylation
• Ubiquitination

• Dephosphorylation
• Demethylation
• Nitration
• Glycosylation
• Oxidation
• Iodination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CRY1

Best Uses Of The CRY1 Marker From Boster Bio

There are many applications that can be used for flow cytometry. The Cry1 Marker by Boster Bio is a great tool in these areas. The marker can be used to detect a wide variety of biologically relevant molecules in particles and cells. The marker is available in monoclonal as well as polyclonal varieties. It is frequently referenced in scientific literature and flow cytometry.

ELISA results for high-sensitivity C reactive proteins

The Human hsCRP ELISA Kit is used to determine high-sensitivity levels in plasma or serum C-reactive proteins. Its detection limit is 0.02ng/ml. This kit is intended for the analysis and measurement of plasma and serum. It is not able to analyze non-biological sources. Therefore, it is not suitable for use in household settings.

The hs–ELISA method has been evaluated for the detection of the hsCRP protein in serum or plasma. The test is available in two formats such as sandwich ELISA or QL-MI. Both formats have the exact sensitivity limit. However, each has a slightly different range. The differences are mainly due to the slight degradation of QD-mAb complexes in the second step.

The hs-CRP assay is of great clinical importance for determining risk factors associated with coronary heart disease. The current methods are difficult to apply in rural areas due to the fact that they require high-end laboratory equipment and low throughput. In order to determine if a person is at risk of developing coronary artery diseases The results of hsCRP ELISA tests are crucial.

The hsCRP assay provides high specificity and sensitivity. The standard CRP range is about 125 ng/L. However the hsCRP range is higher, and the hook effect doesn't appear. It is also available in one-step and two-step formats. The differing sensitivity of these two methods is minimal. However, hs-CRP assays don't require any additional steps in comparison to their counterparts.

hs-CRP is measured by Nephelometry and ELISA. Beckman, Brea (CA) offers the hsCRP ELISA kit. The manufacturer has provided instructions for the tests. Bland-Altman plots were utilized to assess the sensitivity the hsCRP ELIS. These plots were designed using MedCalc version 11.3. They also showed the average fluorescence intensity that was induced by different types of interferences. The results of the hsCRP assay were comparable with those of commercial ELISAs with high-sensitivity.

TNF-a

There are many applications that can be made with the Cry1 marker in both science and medicine. It can measure intracellular cAMP levels and activate protein kinase B and the NF-kB. These are two of the most significant regulatory proteins for proinflammatory genes. They bind to DNA components and regulate transcription. They can be used to detect tumor necrosis factor a and interleukin-6.

IL-6

The Boster Bio CRY1 Marker is an antibody which can be used to identify a variety of targets which include the protein coding gene. The diseases associated with Cry1 include Delayed Sleep Phase Disorder and Sleep Disorder and Circadian Clock. The gene's annotations include nucleotide binding and transcription factor binding. Its paralog is CRY2.