Cone-rod homeobox protein Antibodies

AND CRX ELISA kits, Cone-rod homeobox protein Proteins

Many biological assays use antibodies to detect Cone-rod homeobox protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cone-rod homeobox protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cone-rod homeobox protein antibodies...

We validate the specificity of these antibodies to Cone-rod homeobox protein by testing them on tissues known to express CRX positively and negatively. Browse below to find the CRX antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CRX Infographic by Boster Bio

All CRX Products

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Product

Figures

Specificity

Applications

Price

Anti-CORD2/CRX Antibody Picoband®

2 Q&As

Human

$370
Cat # A02202-1
100 μg/vial

Anti-CRX Monoclonal Antibody

4 Q&As

Human

IHC, WB

$370
Cat # M02202
100 μl

CRX Overview

Facts about Cone-rod homeobox protein.

CRX 3D structure. Source: alphafold

Cone-rod homeobox protein (CRX)

Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of many photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription.

Essential for the maintenance of mammalian photoreceptors. .

Gene Information

Human
Gene Name:	CRX
Uniprot:	O43186
Entrez:	1406

Family

Belongs to:

paired homeobox family

Alternative Names

cone-rod homeobox; CORD2; CRDcone-rod homeobox protein; CRX; LCA7; LCA7orthodenticle homeobox 3; OTX3

Molecular Weight

Mass (kDA):
32.261 kDA

Genomic Context


Human

Location:	19q13.33
Sequence:	19; NC_000019.10 (47821937..47843324)

Tissue Specificity

Retina.

Subcellular Localizations

Nucleus.

Diseases

Retinal Degeneration
Retinitis Pigmentosa
Blind Vision
Leber Congenital Amaurosis
Amaurosis
Dystrophy
Retinal Diseases
Retinal Dystrophies
Retinoblastoma
Abnormal Degeneration
Visual Impairment

Optic Atrophy, Hereditary, Leber
Ataxia, Spinocerebellar
Optic Atrophies, Hereditary
Age Related Macular Degeneration
Ataxia
Neoplasms

Interacting Proteins

ABI2
AES
ATG12
C1orf109
C9orf72

CA8
CCNC
DELE1
EIF5A
GCM2

GUCD1
HGS
LONRF1
M1AP
NIP7

OSGIN1
PID1
PPP1R16B
PRKAB2
PSMB10

QRICH1
SMAD3
SMUG1
SOX5
STK16

UBXN2B

Pathways

Phototransduction
Localization
Eye Development
Cell Differentiation
Pathogenesis
Cell Cycle
Regeneration
Cell Fate Determination
Cell Death
Photoreceptor Cell Fate Determination
Neurogenesis
Photoreceptor Cell Differentiation
Cell Development

Photoreceptor Cell Development
Cell Proliferation
Transport
Secretion
Nuclear Transport
Histone Acetylation
Gland Development

PTMs

Phosphorylation
Acetylation

Glycosylation
Sumoylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CRX

References

PMID: 9390563 by Freund C.L., et al. Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor.

PMID: 17286855 by Roni V., et al. Mapping of transcription start sites of human retina expressed genes.