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CRTC1 Antibodies
AND CRTC1 ELISA kits, CRTC1 Proteins
Many biological assays use antibodies to detect CRTC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CRTC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CRTC1 antibodies...
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CRTC1 Infographic by Boster Bio
All CRTC1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01951-2
100 μg/vial
Cat # A01951-2
100 μg/vial
Human
Flow Cytometry, IP, ICC, WB
$482
Cat # M01951
100ul
Cat # M01951
100ul
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01951-3
100 μg/vial
Cat # A01951-3
100 μg/vial
CRTC1 Overview
Facts about CREB-regulated transcription coactivator 1.
CREB-regulated transcription coactivator 1 (CRTC1)
Transcriptional coactivator for CREB1 which activates transcription via both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being busy when dephosphorylated and acts independently of CREB1'Ser-133' phosphorylation.
Regulates the expression of particular CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | CRTC1 |
| Uniprot: | Q6UUV9 |
| Entrez: | 23373 |
Family
| Belongs to: |
|---|
| TORC family |
Alternative Names
CREB regulated transcription coactivator 1; CRTC1; FLJ14027WAMTP1; KIAA0616Transducer of regulated cAMP response element-binding protein 1; MECT1; MECT1CREB-regulated transcription coactivator 1; mucoepidermoid carcinoma translocated 1; Mucoepidermoid carcinoma translocated protein 1; TORC1; TORC1TORC-1; Transducer of CREB protein 1; transducer of regulated cAMP response element-binding protein (CREB) 1; WAMTP1
Molecular Weight
Mass (kDA):
67.3 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.11 |
| Sequence: | 19; NC_000019.10 (18683621..18782333) |
Tissue Specificity
Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.
Subcellular Localizations
Cytoplasm. Nucleus. Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (PubMed:16817901). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels (PubMed:15589160). Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain (By similarity).
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Mucoepidermoid Carcinoma
- Tuberous Sclerosis
- Sclerosis
- Diabetes Mellitus
- Cell Transformation, Neoplastic
- Hypertrophy
- Salivary Gland Neoplasms
- Insulin Resistance
- Salivary Gland Diseases
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- CREB1
Pathways
- Cell Growth
- Translation
- Autophagy
- Cell Proliferation
- Cell Differentiation
- Aging
- Long-term Memory
- Energy Homeostasis
- Pathogenesis
- Transport
- Localization
- Secretion
- Myelination
PTMs
- Phosphorylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CRTC1
bosterbio.com/bosterbio-gene-info-cards/CRTC1
References
PMID: 14506290 by Iourgenko V., et al. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.
PMID: 12539049 by Tonon G., et al. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.