C-reactive protein Antibodies

C-reactive protein (CRP)

Displays several functions associated with host defense: it boosts agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and might scavenge nuclear material released from cells that are damaged.

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Gene Information

Human
Gene Name:	CRP
Uniprot:	P02741
Entrez:	1401

Family

Belongs to:
pentraxin family

Alternative Names

C-Reactive Protein; C-reactive protein, pentraxin-related; CRP; MGC88244; pentraxin 1; PTX1MGC149895

Molecular Weight

Mass (kDA):
25.039 kDA

Genomic Context

Human
Location:	1q23.2
Sequence:	1; NC_000001.11 (159712289..159714589, complement)

Tissue Specificity

Found in plasma.

Subcellular Localizations

Secreted.

Diseases

• Inflammation
• Cardiovascular Diseases
• Arthritis
• Diabetes Mellitus
• Atherosclerosis
• Rheumatoid Arthritis
• Obesity
• Infective Disorder
• Inflammatory Response
• Malignant Neoplasms
• Infarction
• Myocardial Infarction
• Hypertensive Disease

• Pain
• Coronary Artery Disease
• Heart Diseases
• Coronary Heart Disease
• Insulin Resistance
• Systemic Infection
• Pneumonia

Interacting Proteins

• FCGR2C
• GMPPA

Pathways

• Inflammatory Response
• Pathogenesis
• Secretion
• Coagulation
• Immune Response
• Cell Adhesion
• Excretion
• Acute-phase Response
• Glomerular Filtration
• Complement Activation
• Aging
• Transport
• Virulence

• Platelet Activation
• Localization
• Platelet Aggregation
• Fibrinolysis
• Cytokine Production
• Angiogenesis
• Phagocytosis

PTMs

• Phosphorylation
• Glycosylation
• Oxidation
• Cleavage
• Citrullination
• Nitration
• Reduction
• Biotinylation
• Methylation
• Acylation

• Acetylation
• Carboxylation
• Dephosphorylation
• Iodination
• Amination
• Deamination
• Ubiquitination
• Glutathionylation
• Deacetylation
• Geranylgeranylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CRP

Best Uses of the CRP Marker by Boster Bio

If you are looking to learn more about CRP markers, then you've found the right website. In this article, we'll go over the clinical applications of Boster Bio's CRP Marker, as well as the association between CRP and cardiovascular disease. Other blood tests that can be used to detect the presence of cardiovascular disease are also covered. Continue reading to learn more about CRP Marker and other tests.

Boster Bio's CRP Marker

The CRP Marker is a member of the most well-known acute phase reactants (APRs). It is a non-specific biomarker that rapidly increases in concentration in response to a variety of acute inflammatory events like infection or tissue damage. The circulating CRP level can increase by a thousand-fold over its baseline value. Monitoring CRP levels is vital to manage disease and screen. An increase in CRP levels indicates inflammation.

Its clinical applications

The CRP marker is an essential marker for infectious diseases. Its primary function is to stimulate the activity of the complement system. This is responsible for opsonizing pathogens. In addition to its role in preventing disease, CRP is also useful in the treatment of infections caused by bacteria. Thus, the clinical use of CRP as a marker for infectious disease is increasingly important. This article will give a summary of the clinical applications of CRP.

Patients with CRP levels that are elevated are more at risk of developing cardiovascular disease. Increased levels of CRP are typically related to inflammation. This indicator can help to identify those at a high risk of developing vascular disease. However, CRP levels above 40 mg/L are often indicative of severe malignancies or bacterial infections. There are no definitive guidelines on how to interpret these results. Therefore, clinical practitioners should make use of these markers as a guideline when analyzing the health status of patients.

There is no evidence to support the notion that CRP is present in inflammation cells. It is believed that CRP is connected with inflammatory conditions such as vasculitis, allergic epilepsy and neutrophil infiltrates. It isn't clear how CRP affects these conditions. The research needs to concentrate on determining the exact cause of CRP's activation. This is because CRP markers play an important part in the immune system.

Furthermore, CRP has an independent predictive value for cardiovascular events and adds prognostic information to metabolic syndrome, lipid screening and the Framingham risk score. CRP should be the main diagnostic use of this marker however it can be used as an additional tool to lipid screening. If CRP levels are high, the physician should consider an intervention with pharmacological drugs. This can lead to better patient outcomes and lower cost for cardiovascular care.

Physicians can detect inflammation-related conditions such as atherosclerosis by increasing CRP levels. An abnormally high level of CRP in blood can cause an inflammation response. It is not involved in preventing atherosclerosisbut does promote the apoptosis of human coronary vascular smooth muscle cells. Interestingly, CRP can promote Apoptosis in atherosclerotic plaques via a caspase-mediated mechanism.

CRP is also associated with many pathologies such as diabetes IBD, Alzheimer's disease and cancer. Inflammation can trigger the release of chemical compounds that cause inflammation. Multiple studies have demonstrated the anti-apoptotic benefits of CRP. However, more research is needed to expand these findings and clarify the roles of the various CRP isoforms that are involved in these diseases.

The CRP test is used to determine inflammation in the body. It helps narrow the list of possible causes. It can also assist in determining the severity of the inflammation. The CRP level can be a sign of acute or chronic inflammation. While the test is not without its limitations, it is a reliable marker of inflammation. It is essential in diagnosing any kind of illness or disease. Patients with CRP levels that are high have more serious medical conditions.

It is associated with cardiovascular disease

Researchers discovered that CRP an anti-inflammatory protein, is related to heart disease risk. CRP levels high indicate an increased chance of developing cardiovascular disease. However, the connection between SAA levels and cardiovascular disease is not clear because the soluble ICAM-1 is unstable in vitro. There are at present 30 hs CRP assays available on the market. Diagnostic Products and Iatron Laboratories provide a full range of CRP tests. CRP tests can be ordered in Japan by Wako Pure Chemical Industries or Denka-Seiken.

Despite this confusing finding, hsCRP assessment can be most useful for patients who are at intermediate risk. This group is not recommended for ongoing statin therapy as they are at the lowest risk of developing CVD. Indeed, doubling or increasing their hsCRP would not change their classification or doctors' approach, as their overall risk of CVD will remain minimal. However, those who have an elevated hsCRP are deemed to be at a high risk for CVD, and should receive treatment to lower lipid levels.

This marker is highly sensitive and independent of other risk factors and is the most preferred choice of cardiologist in the treatment of cardiovascular disease. The CRP level can be converted into a CVD risk using a validated classification scheme, and it can be assessed in a variety ways such as risk assessment for cardiovascular events. The CRP level is extremely sensitive to injury, rising between three and one thousandfold and then returning to the baseline level within twelve to fourteen days.

The CRP marker is used to determine the risk of cardiovascular disease. The presence of high levels of this marker indicate high risk of atherosclerosis. This protein is crucial to monitor cholesterol levels. A high CRP level does not necessarily mean you should change your lifestyle. The aim is to lower the risk of heart attacks by improving the quality of your life.

While CRP is an important marker for risk assessment The use of the serum amyloid A protein can aid in determining the severity of cardiovascular disease. Serum amyloid A protein (SAA) is associated with inflammatory processes and has recently been recognized as an important factor in the development of cardiovascular disease. Researchers have concluded that CRP is as effective as SAA in determining the risk of cardiovascular disease.

In the interim, more data are needed to confirm the use of hsCRP to detect intermediate CVD risks. The Centers for Disease Control and Prevention (CDC) however, has decided that hsCRP must be included in risk assessment panels. The test won't be used for screening of the general population in the interim.