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- Table of Contents
, No Gclids
Cornulin Antibodies
AND CRNN ELISA kits, Cornulin Proteins
Many biological assays use antibodies to detect Cornulin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cornulin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cornulin antibodies...
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CRNN Infographic by Boster Bio
All CRNN Products
Product
Figures
Specificity
Applications
Price
Human
IHC, WB
$523
Cat # M06991
100 µl
Cat # M06991
100 µl
CRNN Overview
Facts about Cornulin.
Cornulin (CRNN)
Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation from the induction of G1 arrest.
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Gene Information
| Human | |
|---|---|
| Gene Name: | CRNN |
| Uniprot: | Q9UBG3 |
| Entrez: | 49860 |
Family
| Belongs to: |
|---|
| S100-fused protein family |
Alternative Names
53 kDa squamous epithelial-induced stress protein; 58 kDa heat shock protein; C1orf10; chromosome 1 open reading frame 10; Cornulin; CRNN; DRC1; Gm1015; PDRC1; PDRC1,53 kDa putative calcium-binding protein; SEP53; SEP53C1orf10; Squamous epithelial heat shock protein 53; Tumor-related protein
Molecular Weight
Mass (kDA):
53.533 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q21.3 |
| Sequence: | 1; NC_000001.11 (152409243..152414263, complement) |
Tissue Specificity
Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR).
Subcellular Localizations
Cytoplasm. Does not colocalize with TGM1.
Diseases
- Malignant Neoplasms
- Carcinoma
- Esophageal Neoplasms
- Malignant Squamous Cell Neoplasm
- Neoplasms
- Squamous Cell Carcinoma Of Esophagus
- Esophageal Adenocarcinoma
- Adenocarcinoma
- Gastroesophageal Reflux Disease
- Neoplasm Metastasis
- Tongue Neoplasms
- Tumor Progression
Pathways
- Transport
- Keratinization
- Cell Proliferation
- G1 Phase
- Immune Response
- Keratinocyte Differentiation
- Chemotaxis
- Reverse Transcription
- Cell Cycle
- Cell Death
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CRNN
bosterbio.com/bosterbio-gene-info-cards/CRNN
References
PMID: 11056050 by Xu Z., et al. Novel human esophagus-specific gene c1orf10: cDNA cloning, gene structure, and frequent loss of expression in esophageal cancer.
PMID: 11606197 by Yagui-Beltran A., et al. The human oesophageal squamous epithelium exhibits a novel type of heat shock protein response.