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- Table of Contents
Facts about Cyclic AMP-responsive element-binding protein 3-like protein 1.
In response to ER stress, transported to the Golgi, where it is cleaved at a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The published N-terminal cytosolic domain is translocated into the nucleus to influence transcription of specific target genes.
Mouse | |
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Gene Name: | Creb3l1 |
Uniprot: | Q9Z125 |
Entrez: | 26427 |
Belongs to: |
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bZIP family |
BBF-2 Homolog; cAMP responsive element binding protein 3-like 1; cAMP-responsive element-binding protein 3-like protein 1; CREB3L1; OASIS; OASIScyclic AMP-responsive element-binding protein 3-like protein 1; old astrocyte specifically induced substance; Old astrocyte specifically-induced substance
Mass (kDA):
56.959 kDA
Mouse | |
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Location: | 2|2 E1 |
Sequence: | 2; |
Expressed in cortical and trabecular bones. Highly expressed in osteoblasts, but not detected in osteoclasts, nor in macrophages (PubMed:19767743). Expressed at relatively low levels in lung and kidney. Weakly expressed in brain and spleen.
PMID: 10350641 by Honma Y., et al. Identification of a novel gene, OASIS, which encodes for a putative CREB/ATF family transcription factor in the long-term cultured astrocytes and gliotic tissue.
PMID: 12480185 by Nikaido T., et al. Expression of OASIS, a CREB/ATF family transcription factor, in CNS lesion and its transcriptional activity.