Cyclic AMP-responsive element-binding protein 1 (CREB1)

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation.

Involved in different cellular processes such as the synchronization of circadian rhythmicity and the differentiation of adipose cells. .