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CR1 Antibodies
AND CR1 ELISA kits, CR1 Proteins
Many biological assays use antibodies to detect CR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CR1 antibodies...
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CR1 Infographic by Boster Bio
All CR1 Products
Product
Figures
Specificity
Applications
Price
Cynomolgus monkey, Human, Baboon, Rhesus monkey
Flow Cytometry, IF, IHC
$486
Cat # M01022
100ug/vial
Cat # M01022
100ug/vial
Human, Primate
Flow Cytometry, IP, IHC-P, IHC-F, ICC, WB
$299
Cat # M01022-1
0.1 mg
Cat # M01022-1
0.1 mg
CR1 Overview
Facts about Complement receptor type 1.
Complement receptor type 1 (CR1)
Membrane immune adherence receptor which plays a vital role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes which have activated complement to remove them from the flow (PubMed:2963069).
Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757). Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728).
Gene Information
| Human | |
|---|---|
| Gene Name: | CR1 |
| Uniprot: | P17927 |
| Entrez: | 1378 |
Family
| Belongs to: |
|---|
| receptors of complement activation (RCA) family |
Alternative Names
C3BR; CD35; complement component (3b/4b) receptor 1 (Knops blood group); CR1; KN
Molecular Weight
Mass (kDA):
223.663 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.2 |
| Sequence: | 1; NC_000001.11 (207496152..207641765) |
Tissue Specificity
Present on erythrocytes, a subset of T cells, mature B cells, follicular dendritic cells, monocytes and granulocytes.
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Leukemia
- Leukemia, Myelocytic, Acute
- Myeloid Leukemia
- Lupus Erythematosus, Systemic
- Acute Lymphocytic Leukemia
- Graft-vs-host Disease
- Inflammation
- Tissue Adhesions
- Neoplasms
- Malignant Neoplasms
- Alzheimer's Disease
- Autoimmune Reaction
- Infective Disorder
Pathways
- Phagocytosis
- Complement Activation
- Pathogenesis
- Immune Response
- Opsonization
- Transport
- Localization
- Chemotaxis
- Secretion
- Cell Activation
- Aging
- Proteolysis
- Respiratory Burst
PTMs
- Cleavage
- Phosphorylation
- Glycosylation
- Biotinylation
- Methylation
- Reduction
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CR1
bosterbio.com/bosterbio-gene-info-cards/CR1
References
PMID: 2972794 by Klickstein L.B., et al. Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis.
PMID: 8245463 by Vik D.P., et al. Structure of the gene for the F allele of complement receptor type 1 and sequence of the coding region unique to the S allele.