Complexin-2 Antibodies

AND CPLX2 ELISA kits, Complexin-2 Proteins

Many biological assays use antibodies to detect Complexin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Complexin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Complexin-2 antibodies...

We validate the specificity of these antibodies to Complexin-2 by testing them on tissues known to express CPLX2 positively and negatively. Browse below to find the CPLX2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CPLX2 Infographic by Boster Bio

All CPLX2 Products

Product

Figures

Specificity

Applications

Price

Anti-Complexin-2 CPLX2 Antibody

Human, Mouse, Rat

$405
Cat # A08799
100ul

CPLX2 (NM_006650) Human Recombinant Protein

$1249
Cat # PROTQ6PUV4
20 µg

CPLX2 (NM_006650) Human Over-expression Lysate

Human

$628
Cat # LS010814
100 µg

CPLX2 Overview

Facts about Complexin-2.

CPLX2 3D structure. Source: alphafold

Complexin-2 (CPLX2)

Negatively regulates the formation of synaptic vesicle clustering at active zone into the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of different cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles.

Also included in mast cell exocytosis (By similarity). .

Gene Information

Human
Gene Name:	CPLX2
Uniprot:	Q6PUV4
Entrez:	10814

Family

Belongs to:

complexin/synaphin family

Alternative Names

complexin 2; Complexin II; Complexin-2; CPLX2; CPX II; CPX2; CPX-2; CPX-II; DKFZp547D155; Hfb1; MGC138492; Synaphin 1; synaphin 1,921-L; synaphin-1

Molecular Weight

Mass (kDA):
15.394 kDA

Genomic Context


Human

Location:	5q35.2
Sequence:	5; NC_000005.10 (175796533..175884021)

Tissue Specificity

Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.

Subcellular Localizations

Cytoplasm, cytosol. Cell junction, synapse, presynapse. Nucleus. Perikaryon. Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation.

Diseases

Schizophrenia
Malnutrition
Amnesia
Behcet Syndrome
Nervous System Disorder
Cognition Disorders
Diabetes Mellitus
Psychotic Disorders
Insulin Resistance
Mental Disorders
Memory Disorders

Lesion Of Brain
Autistic Disorder
Inattention
Memory Impairment
Attention Deficit Hyperactivity Disorder
Autism Spectrum Disorders

Pathways

Reverse Transcription
Insulin Secretion
Aging
Immune Response
Synaptic Transmission
Cognition
Localization

Secretion

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CPLX2

References

PMID: 7553862 by McMahon H.T., et al. Complexins: cytosolic proteins that regulate SNAP receptor function.

PMID: 16162394 by Raevskaya N.M., et al. Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity.