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COPS5 Antibodies
AND COPS5 ELISA kits, COPS5 Proteins
Many biological assays use antibodies to detect COPS5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with COPS5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop COPS5 antibodies...
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COPS5 Infographic by Boster Bio
All COPS5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # PB9490
100 μg/vial
Cat # PB9490
100 μg/vial
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M01849
100 μl
Cat # M01849
100 μl
Human, Mouse
ELISA
$480
Cat # EKC1891
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1891
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01849-2
100 μg/vial
Cat # M01849-2
100 μg/vial
COPS5 Overview
Facts about COP9 signalosome complex subunit 5.
COP9 signalosome complex subunit 5 (COPS5)
The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes like SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases.
CSN-dependent phosphorylation of TP53 and JUN protects and promotes degradation from the Ubl system, respectively. In the complex, it probably functions as the catalytic center that mediates the cleavage of Nedd8 from cullins.
Gene Information
| Human | |
|---|---|
| Gene Name: | COPS5 |
| Uniprot: | Q92905 |
| Entrez: | 10987 |
Family
| Belongs to: |
|---|
| peptidase M67A family |
Alternative Names
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); COP9 signalosome complex subunit 5; COPS5; CSN5; CSN5COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 5; EC 3.4; JAB1; JAB138 kDa Mov34 homolog; Jun activation domain-binding protein 1; MOV-34; SGN5; SGN5MGC3149; Signalosome subunit 5
Molecular Weight
Mass (kDA):
37.579 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q13.1 |
| Sequence: | 8; NC_000008.11 (67043079..67062133, complement) |
Subcellular Localizations
Cytoplasm, cytosol. Nucleus. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Nuclear localization is diminished in the presence of IFIT3.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Liver Carcinoma
- Malignant Neoplasm Of Breast
- Liver Neoplasms
- Mammary Neoplasms
- Inflammation
- Neoplasm Metastasis
- Tumor Progression
- Malignant Paraganglionic Neoplasm
- Lymphoma
Interacting Proteins
- CCNDBP1
- CDKN1B
- COPS3
- COPS6
- F2RL1
- GPS1
- IFIT3
- MINDY3
- OPRM1
- RNF20
Pathways
- Cell Cycle
- Cell Proliferation
- Localization
- Nuclear Export
- Pathogenesis
- Cell Growth
- Dna Repair
- S Phase
- Cell Death
- Oncogenesis
- Immune Response
- Cell Cycle Arrest
- Cell Development
PTMs
- Phosphorylation
- Ubiquitination
- Cleavage
- Glycosylation
- Biotinylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COPS5
bosterbio.com/bosterbio-gene-info-cards/COPS5
References
PMID: 8837781 by Claret F.-X., et al. A new group of conserved coactivators that increase the specificity of AP-1 transcription factors.
PMID: 9341143 by Asano K., et al. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.