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COL17A1 Antibodies
AND COL17A1 ELISA kits, COL17A1 Proteins
Many biological assays use antibodies to detect COL17A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with COL17A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop COL17A1 antibodies...
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COL17A1 Infographic by Boster Bio
All COL17A1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M03031
100 μl
Cat # M03031
100 μl
COL17A1 Overview
Facts about Collagen alpha-1(XVII) chain.
Collagen alpha-1(XVII) chain (COL17A1)
May play a part in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. .
Gene Information
| Human | |
|---|---|
| Gene Name: | COL17A1 |
| Uniprot: | Q9UMD9 |
| Entrez: | 1308 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
180 kDa bullous pemphigoid antigen 2; BA16H23.2; BP180; BP180alpha 1 type XVII collagen; BPA-2; BPAG2; BPAG2bA16H23.2 (collagen, type XVII, alpha 1 (BP180)); bullous pemphigoid antigen 2 (180kD); Bullous pemphigoid antigen 2; COL17A1; Collagen 17; collagen alpha-1(XVII) chain; Collagen XVII; collagen XVII, alpha-1 polypeptide; collagen, type XVII, alpha 1; Collagen-17; ERED; FLJ60881; KIAA0204; LAD-1
Molecular Weight
Mass (kDA):
150.419 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q25.1 |
| Sequence: | 10; NC_000010.11 (104031286..104085880, complement) |
Tissue Specificity
Detected in skin (PubMed:8618013). In the cornea, it is detected in the epithelial basement membrane, the epithelial cells, and at a lower level in stromal cells (at protein level) (PubMed:25676728). Stratified squamous epithelia. Found in hemidesmosomes. Expressed in cornea, oral mucosa, esophagus, intestine, kidney collecting ducts, ureter, bladder, urethra and thymus but is absent in lung, blood vessels, skeletal muscle and nerves.
Subcellular Localizations
Cell junction, hemidesmosome. Membrane; Single-pass type II membrane protein. Localized along the plasma membrane of the hemidesmosome.; [120 kDa linear IgA disease antigen]: Secreted, extracellular space, extracellular matrix, basement membrane. Exclusively localized to anchoring filaments. Localized to the epidermal side of split skin.; [97 kDa linear IgA disease antigen]: Secreted, extracellular space, extracellular matrix, basement membrane. Localized in the lamina lucida beneath the hemidesmosomes.
Diseases
- Epidermolysis Bullosa
- Junctional Epidermolysis Bullosa
- Bulla
- Bullous Pemphigoid
- Dermatologic Disorders
- Atrophy
- Dystrophy
- Dystrophia Unguium
- Tissue Adhesions
- Skin Diseases, Genetic
- Embryonic Mosaic
- Epidermolysis Bullosa Dystrophica
Pathways
- Cell Adhesion
- Gene Conversion
- Translation
- Amelogenesis
- Pathogenesis
- Stem Cell Maintenance
- Glycosylation
- Proteolysis
- Skin Development
- Keratinocyte Migration
PTMs
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COL17A1
bosterbio.com/bosterbio-gene-info-cards/COL17A1
References
PMID: 1324962 by Giudice G.J., et al. Cloning and primary structural analysis of the bullous pemphigoid autoantigen, BP180.
PMID: 9012408 by Gatalica B., et al. Cloning of the human type XVII collagen gene (COL17A1), and detection of novel mutations in generalized atrophic benign epidermolysis bullosa.