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Clathrin heavy chain 1 Antibodies
AND CLTC ELISA kits, Clathrin heavy chain 1 Proteins
Many biological assays use antibodies to detect Clathrin heavy chain 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Clathrin heavy chain 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Clathrin heavy chain 1 antibodies...
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CLTC Infographic by Boster Bio
All CLTC Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M03134
100 μl
Cat # M03134
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03134-1
100 μg/vial
Cat # A03134-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M03134-2
100 μg/vial
Cat # M03134-2
100 μg/vial
CLTC Overview
Facts about Clathrin heavy chain 1.
Clathrin heavy chain 1 (CLTC)
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
Acts as component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter- microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825).
Gene Information
| Human | |
|---|---|
| Gene Name: | CLTC |
| Uniprot: | Q00610 |
| Entrez: | 1213 |
Family
| Belongs to: |
|---|
| clathrin heavy chain family |
Alternative Names
CHC; CHC17; Clathrin Heavy Chain 1; Clathrin heavy chain on chromosome 17; clathrin, heavy chain (Hc); clathrin, heavy chain; clathrin, heavy polypeptide (Hc); clathrin, heavy polypeptide-like 2; CLH17; CLH-17; CLTC; CLTCL2; Hc; KIAA0034
Molecular Weight
Mass (kDA):
191.615 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q23.1 |
| Sequence: | 17; NC_000017.11 (59619689..59696956) |
Subcellular Localizations
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Melanosome. Cytoplasm, cytoskeleton, spindle. Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles.
Diseases
- Neoplasms
- Lymphoma
- Diffuse Large B-cell Lymphoma
- Anaplastic Lymphoma
- B-cell Lymphomas
- Chromosomal Translocation
- Carcinoma
- Ki-1+ Anaplastic Large Cell Lymphoma
- Malignant Neoplasms
- Renal Cell Carcinoma
- Kidney Neoplasm
- Adenocarcinoma
Interacting Proteins
- CLTA
- HIP1
- MYB
- OCRL
- TNK2
- TOM1L1
Pathways
- Endocytosis
- Clathrin-mediated Endocytosis
- Localization
- Pathogenesis
- Mitosis
- Metaphase
- Rna Interference
- Receptor-mediated Endocytosis
- Aging
- Membrane Organization
- Pigmentation
- Plasma Cell Differentiation
- Oocyte Maturation
PTMs
Research Areas
- Membrane Vesicle Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLTC
bosterbio.com/bosterbio-gene-info-cards/CLTC
References
PMID: 1765375 by Dodge G.R., et al. Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter.
PMID: 11532990 by Waelter S., et al. The huntingtin interacting protein HIP1 is a clathrin and alpha- adaptin-binding protein involved in receptor-mediated endocytosis.