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, No Gclids
CLK2 Antibodies
AND CLK2 ELISA kits, CLK2 Proteins
Many biological assays use antibodies to detect CLK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLK2 antibodies...
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CLK2 Infographic by Boster Bio
All CLK2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1731
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1731
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A05206-2
100 μg/vial
Cat # A05206-2
100 μg/vial
CLK2 Overview
Facts about Dual specificity protein kinase CLK2.
Dual specificity protein kinase CLK2 (CLK2)
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex.
May be a part of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can lead to redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes through its phosphorylation.
Gene Information
| Human | |
|---|---|
| Gene Name: | CLK2 |
| Uniprot: | P49760 |
| Entrez: | 1196 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
CDC-like kinase 2CLK kinase; clk2; dual specificity protein kinase CLK2; EC 2.7.12.1; hCLK2; MGC61500
Molecular Weight
Mass (kDA):
60.09 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q22 |
| Sequence: | 1; NC_000001.11 (155262868..155273504, complement) |
Tissue Specificity
Endothelial cells.
Subcellular Localizations
Nucleus.; [Isoform 1]: Nucleus. Nucleus speckle. Inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle.; [Isoform 2]: Nucleus speckle. Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles.
Diseases
- Acute Erythroblastic Leukemia
- Ataxia
- Dementia
- Insulin Resistance
- Malignant Neoplasms
- Neoplasms
- Nervousness
- Pancreatic Neoplasm
- Lymphoma
- Cytogenetic Abnormality
- Dysequilibrium Syndrome
- Trematode Infections
Interacting Proteins
- CLK3
- CPSF7
- ECE1
- KLHL2
- LNX1
- LUZP4
- MRPL4
- PRPF38A
- RBM39
- RSRP1
Pathways
- Gluconeogenesis
- Localization
- Hyperphosphorylation
- Insulin Secretion
- Brain Development
- Aging
- Dna Replication
- Cell Death
- Cellular Localization
- Cell Cycle
PTMs
- Phosphorylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLK2
bosterbio.com/bosterbio-gene-info-cards/CLK2
References
PMID: 7990150 by Hanes J.J., et al. Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.
PMID: 9331372 by Winfield S.L., et al. Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease.