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, No Gclids
CLIP1 Antibodies
AND CLIP1 ELISA kits, CLIP1 Proteins
Many biological assays use antibodies to detect CLIP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLIP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLIP1 antibodies...
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CLIP1 Overview
Facts about CAP-Gly domain-containing linker protein 1.
CAP-Gly domain-containing linker protein 1 (CLIP1)
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling.
Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.
Gene Information
| Human | |
|---|---|
| Gene Name: | CLIP1 |
| Uniprot: | P30622 |
| Entrez: | 6249 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CAP-GLY domain containing linker protein 1; CLIP; CLIP170; CLIP-170Reed-Sternberg intermediate filament-associated protein; CYLN1MGC131604; cytoplasmic linker 1; Cytoplasmic linker protein 1; Cytoplasmic linker protein 170 alpha-2; Reed-Steinberg cell-expressed intermediate filament-associated protein; restin (Reed-Steinberg cell-expressed intermediate filament-associated protein); Restin; RSNCAP-Gly domain-containing linker protein 1
Molecular Weight
Mass (kDA):
162.246 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.31 |
| Sequence: | 12; NC_000012.12 (122271431..122422956, complement) |
Tissue Specificity
Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease.
Subcellular Localizations
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Localizes to microtubule plus ends (PubMed:21646404, PubMed:17889670). Localizes preferentially to the ends of tyrosinated microtubules (By similarity). Accumulates in plasma membrane regions with ruffling and protrusions. Associates with the membranes of intermediate macropinocytic vesicles (PubMed:12433698).
Diseases
- Neuroblastoma
- Cell Transformation, Neoplastic
- Acute Lymphocytic Leukemia
- Autoimmune Diseases
- Diphtheria
- Leukemia, Myelocytic, Acute
- Autoimmune Reaction
- Acute Leukemia
- Malignant Neoplasms
Interacting Proteins
- DCTN1
- MAPRE1
- TUBA1A
- TUBA4A
Pathways
- Receptor-mediated Endocytosis
- Transport
- Intracellular Transport
- Cell Activation
- Gastrulation
- Cell Cycle
- Cell Motility
- S Phase
PTMs
Research Areas
- Dendritic Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLIP1
bosterbio.com/bosterbio-gene-info-cards/CLIP1
References
PMID: 1600942 by Bilbe G., et al. Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease.
PMID: 1356075 by Pierre P., et al. CLIP-170 links endocytic vesicles to microtubules.