CLEC2D Antibodies

AND CLEC2D ELISA kits, CLEC2D Proteins

Many biological assays use antibodies to detect CLEC2D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLEC2D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLEC2D antibodies...

We validate the specificity of these antibodies to CLEC2D by testing them on tissues known to express CLEC2D positively and negatively. Browse below to find the CLEC2D antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CLEC2D Infographic by Boster Bio

All CLEC2D Products

Product

Figures

Specificity

Applications

Price

Anti-CLC2D CLEC2D Antibody

Human, Mouse

ELISA, WB

$380
Cat # A06635
100ul

Human OCIL/CLEC2d Recombinant Protein

SDS-PAGE, Denatured

$250
Cat # PROTQ9UHP7
Starting from 20ug

CLEC2D (NM_013269) Human Over-expression Lysate

Human

$628
Cat # LS029121
100 µg

CLEC2D Overview

Facts about C-type lectin domain family 2 member D.

CLEC2D 3D structure. Source: alphafold

C-type lectin domain family 2 member D (CLEC2D)

Receptor for KLRB1 that protects target cells from natural killer cell-mediated lysis (PubMed:20843815, PubMed:16339513). Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656).

Inhibits bone resorption (PubMed:14753741). Modulates the launch of interferon-gamma (PubMed:15104121).

Gene Information

Human
Gene Name:	CLEC2D
Uniprot:	Q9UHP7
Entrez:	29121

Family

Belongs to:

No superfamily

Alternative Names

CLAXLLT-1; CLEC2D; C-type lectin domain family 2 member D; C-type lectin domain family 2, member D; C-type lectin related f; Lectin-like NK cell receptor; Lectin-like transcript 1; LLT1; LLT1Osteoclast inhibitory lectin; OCIL; OCILmember D

Molecular Weight

Mass (kDA):
21.849 kDA

Genomic Context


Human

Location:	12p13.31
Sequence:	12; NC_000012.12 (9669713..9699553)

Tissue Specificity

Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells.

Subcellular Localizations

Cell membrane; Single-pass type II membrane protein.; [Isoform 2]: Endoplasmic reticulum.; [Isoform 4]: Endoplasmic reticulum.

Diseases

Neoplasms
Malignant Neoplasms
Lupus Erythematosus, Systemic
Virus Diseases
Cholangiocarcinoma
Autoimmunity
Inflammatory Bowel Diseases
Glioma
Hematopoietic Neoplasms
Intestinal Diseases
Sarcoma
Ulcer
Rheumatism

Osteosarcoma
Innate Immune Response
Lymphoma
Rheumatoid Arthritis
Dysequilibrium Syndrome
Colitis
Cell Invasion

Interacting Proteins

KLRB1

Pathways

Osteoclast Differentiation
Secretion
Bone Resorption
Nk T Cell Proliferation
Cytokine Production
Cytolysis
Cell Proliferation
Cell-cell Recognition

Osteoblast Differentiation
T Cell Proliferation
Pathogenesis

PTMs

Phosphorylation

Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLEC2D

References

PMID: 10541800 by Boles K.S., et al. Cloning of a new lectin-like receptor expressed on human NK cells.

PMID: 14753741 by Hu Y.S., et al. Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts.