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CLCNKA Antibodies

AND CLCNKA ELISA kits, CLCNKA Proteins

Many biological assays use antibodies to detect CLCNKA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLCNKA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLCNKA antibodies...

We validate the specificity of these antibodies to CLCNKA by testing them on tissues known to express CLCNKA positively and negatively. Browse below to find the CLCNKA antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CLCNKA Infographic by Boster Bio

CLCNKA protein infographic

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Anti-CLCNKA/Clc Ka Antibody

7 Q&As

Human

WB

$360
Cat # A06425
100 µl

CLCNKA Overview

Facts about Chloride channel protein ClC-Ka.

CLCNKA 3D structure

CLCNKA 3D structure. Source: alphafold

Chloride channel protein ClC-Ka (CLCNKA)

Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.

May be important in urinary concentrating mechanisms. .

Gene Information

Human
Gene Name:	CLCNKA
Uniprot:	P51800
Entrez:	1187

Gene Information

Family

Belongs to:

chloride channel (TC 2.A.49) family

Family

Alternative Names

chloride channel KaMGC61490; hClC-Ka; kidney, A

Molecular Weight

Mass (kDA):
75.285 kDA

Molecular Weight

Genomic Context


Human

Location:	1p36.13
Sequence:	1; NC_000001.11 (16022036..16034050)

Tissue Specificity

Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proteins.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Subcellular Localization

Diseases

Bartter Disease
Disease Of Adrenal Medulla
Complete Hearing Loss
Diabetes Mellitus
Nephrogenic Diabetes Insipidus
Hypertensive Disease
Kidney Diseases
Heart Failure
Dehydration
Sensorineural Hearing Loss (disorder)
Alkalosis
Dysequilibrium Syndrome

Deprivation Of Water
Dent's Disease
Metabolic Alkalosis
Congenital Nephrogenic Diabetes Insipidus
Cardiac Failure Chronic
Deafness Congenital

Disease

Pathways

Transport
Localization
Chloride Transport
Transepithelial Chloride Transport
Pathogenesis
Cellular Localization
Water Homeostasis
Kidney Development
Secretion
Protein Phosphorylation
Ion Transport
Endocytosis
Diuresis

Regulation Of Transport
Transepithelial Transport
Cell Division
Antiport
Amino Acid Transport
Water Transport
Regulation Of Ion Transport

Pathways

PTMs

Phosphorylation

Glycosylation

Bosterbio | ELISA Kits, Antibodies, Antibody Company

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLCNKA

References

PMID: 8041726 by Kieferle S., et al. Two highly homologous members of the ClC chloride channel family in both rat and human kidney.

PMID: 11734858 by Estevez R., et al. Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion.