CLCN6 Antibodies

AND CLCN6 ELISA kits, CLCN6 Proteins

Many biological assays use antibodies to detect CLCN6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLCN6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLCN6 antibodies...

We validate the specificity of these antibodies to CLCN6 by testing them on tissues known to express CLCN6 positively and negatively. Browse below to find the CLCN6 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CLCN6 Infographic by Boster Bio

All CLCN6 Products

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Specificity

Applications

Price

Anti-CLC-6 CLCN6 Antibody

4 Q&As

Human, Monkey, Mouse, Rat

$399
Cat # A07500
100μl

CLCN6 (NM_021737) Human Over-expression Lysate

Human

$628
Cat # LS001185
100 µg

CLCN6 Overview

Facts about Chloride transport protein 6.

CLCN6 3D structure. Source: alphafold

Chloride transport protein 6 (CLCN6)

Chloride transport protein, originally identified as voltage-gated chloride channel. The presence of this conserved gating glutamate residues suggests that is acts as antiporter.

Gene Information

Human
Gene Name:	CLCN6
Uniprot:	P51797
Entrez:	1185

Family

Belongs to:

chloride channel (TC 2.A.49) family

Alternative Names

chloride channel 6; Chloride channel protein 6; chloride transport protein 6; ClC-6; KIAA0046CLC-6

Molecular Weight

Mass (kDA):
97.289 kDA

Genomic Context


Human

Location:	1p36.22
Sequence:	1; NC_000001.11 (11806096..11843144)

Tissue Specificity

Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform 3 is only detected in kidney.

Subcellular Localizations

Endosome membrane; Multi-pass membrane protein. Detected in detergent-resistant lipid rafts.

Diseases

Nervousness
Neuronal Ceroid-lipofuscinoses
Edema
Lysosomal Storage Diseases
5,10-methylenetetrahydrofolate Reductase Deficiency
Cystic Fibrosis
Disease Of Adrenal Medulla
Dent's Disease
Dementia
Oculocerebrorenal Syndrome
Endometriosis, Site Unspecified
Fibrosis

Neoplasms
Pain
Neuroblastoma
Nerve Degeneration
Intraocular Pressure Disorder
Heart Failure

Pathways

Transport
Localization
Chloride Transport
Glycosylation
Lung Development
Endocytosis
Lung Growth
Methylation
Transepithelial Transport

Membrane Depolarization
Translation
Pathogenesis
Secretion

PTMs

Glycosylation

Cleavage

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLCN6

References

PMID: 8543009 by Brandt S., et al. ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family.

PMID: 9224655 by Eggermont J., et al. Alternative splicing of ClC-6 (a member of the ClC chloride-channel family) transcripts generates three truncated isoforms one of which, ClC-6c, is kidney-specific.