CKAP2 Antibodies

AND CKAP2 ELISA kits, CKAP2 Proteins

Many biological assays use antibodies to detect CKAP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CKAP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CKAP2 antibodies...

We validate the specificity of these antibodies to CKAP2 by testing them on tissues known to express CKAP2 positively and negatively. Browse below to find the CKAP2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CKAP2 Infographic by Boster Bio

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CKAP2 (NM_018204) Human Over-expression Lysate

Human

$628
Cat # LS026586
100 µg

CKAP2 Overview

Facts about Cytoskeleton-associated protein 2.

CKAP2 3D structure. Source: alphafold

Cytoskeleton-associated protein 2 (CKAP2)

Possesses microtubule stabilizing properties. Participate in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent way (By similarity).

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Gene Information

Human
Gene Name:	CKAP2
Uniprot:	Q8WWK9
Entrez:	26586

Family

Belongs to:

CKAP2 family

Alternative Names

CTCL tumor antigen se20-10; cytoskeleton associated protein 2; cytoskeleton-associated protein 2; LB1DKFZp686L1238; se20-10; TMAPFLJ10749; Tumor- and microtubule-associated protein; tumor-associated microtubule-associated protein

Molecular Weight

Mass (kDA):
76.987 kDA

Genomic Context


Human

Location:	13q14.3
Sequence:	13; NC_000013.11 (52455360..52476631)

Tissue Specificity

Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney.

Subcellular Localizations

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.

Diseases

Neoplasms
Malignant Neoplasms
Cell Transformation, Neoplastic
Lymphoma
Diffuse Large B-cell Lymphoma
B-cell Lymphomas
Malignant Neoplasm Of Stomach
Stomach Neoplasms
Adenoma
Drug-induced Liver Injury
Malignant Neoplasm Of Breast
Malignant Tumor Of Colon

Hypoxia
Aneuploidy
Neoplasm Invasiveness
Macrocephaly
Mammary Neoplasms
Hepatotoxicity
Adenocarcinoma

Pathways

Mitosis
Chromosome Segregation
Cell Cycle
Cell Proliferation
Anaphase
Cell Cycle Arrest
Cytokinesis
Prophase
Cell Division
Spindle Assembly
Oncogenesis
G1 Phase
Metaphase

Localization
Cellular Senescence
Cell Maturation
Centrosome Separation
Chromatin Organization
Bone Development
Epithelial To Mesenchymal Transition

PTMs

Phosphorylation

Dephosphorylation

Ubiquitination

Research Areas

Core ESC-Like Genes
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CKAP2

References

PMID: 9771967 by Maouche-Chretien L., et al. Identification of a novel cDNA, encoding a cytoskeletal associated protein, differentially expressed in diffuse large B-cell lymphomas.

PMID: 11234418 by Udina I.G., et al. Evolutionarily-conserved gene CKAP2,located in region 13q14.3 of the human genome, is frequently rearranged in various tumors.