CILP Antibodies

AND CILP ELISA kits, CILP Proteins

Many biological assays use antibodies to detect CILP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CILP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CILP antibodies...

We validate the specificity of these antibodies to CILP by testing them on tissues known to express CILP positively and negatively. Browse below to find the CILP antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CILP Infographic by Boster Bio

All CILP Products

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Product

Figures

Specificity

Applications

Price

Human CILP ELISA Kit PicoKine®

5 Q&As

Human

ELISA

$499
Cat # EK1986
96 wells/kit, with removable strips.

Anti-CILP1 Antibody

Human

ELISA, WB

$380
Cat # A06239
100ul

CILP (NM_003613) Human Over-expression Lysate

Human

$628
Cat # LS008483
100 µg

CILP Overview

Facts about Cartilage intermediate layer protein 1.

CILP 3D structure. Source: alphafold

Cartilage intermediate layer protein 1 (CILP)

Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions.

Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1.

Gene Information

Human
Gene Name:	CILP
Uniprot:	O75339
Entrez:	8483

Family

Belongs to:

No superfamily

Alternative Names

cartilage intermediate layer protein 1 C1; cartilage intermediate layer protein 1 C2; cartilage intermediate layer protein 1; cartilage intermediate layer protein, nucleotide pyrophosphohydrolase; Cartilage intermediate-layer protein; CILP; CILP1; CILP-1; HsT18872

Molecular Weight

Mass (kDA):
132.565 kDA

Genomic Context


Human

Location:	15q22.31
Sequence:	15; NC_000015.10 (65194760..65213142, complement)

Tissue Specificity

Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in hip articular cartilage. Overexpressed in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease (CPPD). Expression in intervertebral disk tissue from individuals with lumbar disk disease increases as disk degeneration progresses.

Subcellular Localizations

Secreted, extracellular space, extracellular matrix.

Diseases

Degenerative Polyarthritis
Intervertebral Disc Degeneration
Calcium Pyrophosphate Deposition Disease
Lumbar Disc Disease
Osteoarthritis, Knee
Arthritis
Intervertebral Disk Displacement
Rheumatoid Arthritis
Arthropathy
Lumbar Disc Degenerative Disorder
Abnormal Degeneration
Penile Lesion

Autoimmunity
Cholangiocarcinoma
Spinal Diseases
Arthritis, Reactive
Brain Ischemia
Tendon Calcification
Coronary Artery Disease

Pathways

Aging
Immune Response
Pathogenesis
Localization
Secretion
Transport
Translation
Cholesterol Esterification

Extracellular Transport
Tropism

PTMs

Glycosylation
Phosphorylation

Cleavage
Citrullination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CILP

References

PMID: 9722584 by Lorenzo P., et al. Cloning and deduced amino acid sequence of a novel cartilage protein (CILP) identifies a proform including a nucleotide pyrophosphohydrolase.

PMID: 10319588 by Nakamura I., et al. Genomic organization, mapping, and polymorphisms of the gene encoding human cartilage intermediate layer protein (CILP).