CHTOP Antibodies

AND CHTOP ELISA kits, CHTOP Proteins

Many biological assays use antibodies to detect CHTOP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHTOP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHTOP antibodies...

We validate the specificity of these antibodies to CHTOP by testing them on tissues known to express CHTOP positively and negatively. Browse below to find the CHTOP antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CHTOP Infographic by Boster Bio

All CHTOP Products

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Product

Figures

Specificity

Applications

Price

Anti-C1orf77/FOP/CHTOP Antibody Picoband®

Human, Monkey, Mouse, Rat

Flow Cytometry, IHC, WB

$370
Cat # A07770-2
100 μg/vial

C1orf77 (CHTOP) (NM_015607) Human Over-expression Lysate

Human

$628
Cat # LS026097
100 µg

CHTOP Overview

Facts about Chromatin target of PRMT1 protein.

CHTOP 3D structure. Source: alphafold

Chromatin target of PRMT1 protein (CHTOP)

Plays an important part in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955).

Recruits the 5FMC complicated to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important part in the tumorigenicity of glioblastoma cells.

Gene Information

Human
Gene Name:	CHTOP
Uniprot:	Q9Y3Y2
Entrez:	26097

Family

Belongs to:

No superfamily

Alternative Names

C1orf77; chromatin target of PRMT1; DKFZP547E1010; FOPMGC86949; Friend of PRMT1 protein; MGC131924; pp7704; RP1-178F15.2; Small arginine- and glycine-rich protein; small protein rich in arginine and glycine; SRAGchromosome 1 open reading frame 77

Molecular Weight

Mass (kDA):
26.397 kDA

Genomic Context


Human

Location:	1q21.3
Sequence:	1; NC_000001.11 (153633982..153646306)

Tissue Specificity

Expressed in an erythroid progenitor cell line derived from peripheral blood. Expressed in glioblastoma cells (PubMed:25284789).

Subcellular Localizations

Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Mostly associated with facultative heterochromatin (By similarity). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (PubMed:23826332).

Diseases

Anemia, Sickle Cell

Interacting Proteins

ALYREF
DDX39B
ERH
KHDRBS2
NXF1

PRMT1
SMN1

Pathways

Methylation
Cell Proliferation
Cell Death
Cell Cycle
Mitosis
Proteolysis

Localization

PTMs

Methylation

Sumoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHTOP

References

PMID: 19254951 by Zullo A.J., et al. Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation.

PMID: 20688955 by van Dijk T.B., et al. Fetal globin expression is regulated by Friend of Prmt1.