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CHST10 Antibodies
AND CHST10 ELISA kits, CHST10 Proteins
Many biological assays use antibodies to detect CHST10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHST10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHST10 antibodies...
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CHST10 Infographic by Boster Bio
All CHST10 Products
Product
Figures
Specificity
Applications
Price
Anti-CHST10/Hnk 1St Antibody
1 Q&As
Human, Mouse, Rat
ELISA, IHC-P, WB, IF (paraffin)
$335
Cat # A30586
100ul
Cat # A30586
100ul
CHST10 Overview
Facts about Carbohydrate sulfotransferase 10.
Carbohydrate sulfotransferase 10 (CHST10)
Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue taken by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult.
May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CHST10 |
| Uniprot: | O43529 |
| Entrez: | 9486 |
Family
| Belongs to: |
|---|
| sulfotransferase 2 family |
Alternative Names
Carbohydrate Sulfotransferase 10; CHST10; EC 2.8.2; HNK-1 sulfotransferase; HNK1ST; HNK-1STEC 2.8.2.-; HNK1STHuHNK-1ST; huHNK-1ST; MGC17148
Molecular Weight
Mass (kDA):
42.207 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q11.2 |
| Sequence: | 2; NC_000002.12 (100391860..100417668, complement) |
Tissue Specificity
In fetal tissues, it is predominantly expressed in brain, and weakly expressed in lung, kidney and liver. In adult, it is highly expressed in brain, testis, ovary, expressed at intermediate level in heart, pancreas, skeletal muscle, spleen and thymus, and weakly expressed in other tissues. In brain, it is expressed at higher level in the frontal lobe.
Subcellular Localizations
Golgi apparatus membrane; Single-pass type II membrane protein.
Diseases
- Tissue Adhesions
- Nervousness
- Melanoma
- Crest Syndrome
- Inflammation
- Cell Invasion
- Learning Disorders
- Neoplasm Metastasis
- Nerve Damage
- Chronic Inflammation
- Schizophrenia
- Atrophy
Pathways
- Cell Adhesion
- Cell Migration
- Glycosylation
- Sulfation
- Synaptic Transmission
- Localization
- Cell-cell Recognition
- Neural Crest Cell Migration
- Neuron Migration
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHST10
bosterbio.com/bosterbio-gene-info-cards/CHST10
References
PMID: 9478973 by Ong E., et al. Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids.
PMID: 10464296 by Ong E., et al. Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis.