CHRM2 Antibodies

Muscarinic acetylcholine receptor M2 (CHRM2)

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.

Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release to the cytosol. .

Gene Information

Human
Gene Name:	CHRM2
Uniprot:	P08172
Entrez:	1129

Family

Belongs to:
G-protein coupled receptor 1 family

Alternative Names

7TM receptor; cholinergic receptor, muscarinic 2; CHRM2; FLJ43243; HM2; mAChR M2; MGC120006; MGC120007; muscarinic acetylcholine receptor M2; muscarinic M2 receptor

Molecular Weight

Mass (kDA):
51.715 kDA

Genomic Context

Human
Location:	7q33
Sequence:	7; NC_000007.14 (136868637..137020255)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Phosphorylation in response to agonist binding promotes receptor internalization.

Diseases

• Depressive Disorder
• Mental Disorders
• Major Depressive Disorder
• Substance-related Disorders
• Dysequilibrium Syndrome
• Nervousness
• Social Disinhibition
• Personality Disorders
• Antisocial Personality Disorder
• Hereditary Diseases
• Nicotine Dependence

• Inflammation
• Cardiac Arrhythmia
• Depressive Syndromes
• Bipolar Disorder
• Schizophrenia
• Cognition Disorders

Pathways

• Cognition
• Pathogenesis
• Methylation
• System Development
• Prepulse Inhibition
• Nervous System Development
• Glycosylation
• Response To Nicotine

• Central Nervous System Development
• Innervation
• Localization

PTMs

• Methylation

Research Areas

• GPCR
• Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHRM2

Boster Bio: Best Uses Of The CHRM2 Marker

This article will provide a basic overview of Boster Bio: Best Uses of The ChRM2 Marker Steven Boster's history, and the applications of this marker. This article will provide additional information about Boster Bio's background as well as the history of the company. If you are interested in this product, continue reading! It is a fantastic product that can be used in a variety of areas, such as agriculture, medicine, or agriculture.

Boster Bio Anti-CHRM2 Marker

Boster Bio's Anti -CHRM2 antibody forms part of the Picoband(tm) and has been examined against mouse, human and rats. Its sensitiveness and affinity are both high, making it an excellent option for ELISA and IHC applications. This antibody is suitable for use in immunohistochemistry, histology, cellular signaling, and other applications.

Best Uses of the CHRM2 Marker

The CHRM2 gene is composed of six isoforms, and its promoter region is upstream of exon 1. In humans the transcriptional transcripts of CHRM2 are expressed throughout the brain and are normalized to other genes that are vital for brain's housekeeping functions. Despite the fact that CHRM2 gene expression is extremely variable, it does not have a clear connection with the individual CHRM2 genotypes.

Multiple single nucleotide polymorphisms (SNPs) that alter the function or cause a difference in susceptibility to disease, are known to be found in this gene. A positive anti-CHRM2 score is defined by a ratio higher than 2.1. We also estimated 3-year survival using the Kaplan-Meier method. The data were analyzed using the GraphPad 4.0 software package.

Steven Boster's story

The first product produced by Steven Boster's company was created in 1993 and was dubbed "the lavatory of science." He then developed hundreds of primary antibodies and was the biggest catalog antibody company in China. His ELISA kits utilized trade secrets developed by the company to create high-sensitivity ELISAs. Steven Boster's career has been filled with memorable and regular events. Continue reading to find out more about Steven's past.

Steve Boster was the son of James and Evelyn Meier. He was born in Joliet (IL). He was a veteran of the U.S. Army, and was a Concordia Hall member in Staunton. He is also survived by 4 Brothers Boster - Donald, Sr., David Boster, and Jack. He is also survived by several nieces and nephews.

The CHRM2 Marker is used in a variety of applications.

The CHRM2 gene is located on 7q31-q35 chromosome. The gene undergoes a transition C-G at nucleotide 722 , which results in an Cys176Trp mutant. This marker is useful for identifying common single nucleotide polymorphisms. The CHRM2 marker has many applications for testing genetics and prevention of diseases.

A mutation in the CHRM2 gene has been associated with familial DCM. The Cys176Trp amino acids replace an amino that is highly conserved. The mutation carriers test positive for the anti-CHRM2 antibody and have a Cys176Trp substitution in the product of the gene. The mutation carriers are older than non-carriers and have a greater mortality rate after a three-year follow-up.

The CHRM2 gene is located in the cholinergic system. It is involved in a variety of cognitive processes. It has been associated with the degree of intelligence (IQ) in humans. It is also associated to memory. Cholinergic pathways are often linked to IQ which is a major part of cognition. This gene could be one of the candidates for a marker of cognitive ability however, there are no known polymorphisms.

Genetic studies have revealed that CHRM2 polymorphism could explain individual genetic variations in susceptibility to SD. Six CHRM2 markers were tested in 871 individuals in two recent studies. One study involved healthy controls of 333 (European, African) and 415 SD subjects (346 DD), who were affected by the mutation C722G. These results support the hypothesis of a C722G mutation being associated with DCM. It is important to note that autoantibodies don't provide reliable indicators for diagnosing SD.