CHRM2 Antibodies

AND CHRM2 ELISA kits, CHRM2 Proteins

Many biological assays use antibodies to detect CHRM2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHRM2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHRM2 antibodies...

We validate the specificity of these antibodies to CHRM2 by testing them on tissues known to express CHRM2 positively and negatively. Browse below to find the CHRM2 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CHRM2 Infographic by Boster Bio

All CHRM2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Muscarinic Acetylcholine Receptor 2/CHRM2 Antibody Picoband®

3 Q&As

Human, Mouse, Rat

IHC, WB

$370
Cat # PA1325-1
100 μg/vial

Anti-Muscarinic Acetylcholine Receptor 2/CHRM2 Antibody Picoband®

Human, Mouse, Rat

$370
Cat # A02733
100 μg/vial

Anti-CHRM2 Antibody

Human, Mouse

Flow Cytometry, IF, IHC-P, WB

$299
Cat # M02733
80 µl

Anti-ACM2 Rabbit Monoclonal Antibody

Human, Mouse, Rat

IP, IHC, WB

$370
Cat # M02733-1
100 μl/vial

CHRM2 (NM_001006630) Human Over-expression Lysate

Human

$960
Cat # LS001129
100 µg

CHRM2 Overview

Facts about Muscarinic acetylcholine receptor M2.

CHRM2 3D structure. Source: alphafold

Muscarinic acetylcholine receptor M2 (CHRM2)

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.

Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release to the cytosol. .

Gene Information

Human
Gene Name:	CHRM2
Uniprot:	P08172
Entrez:	1129

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

7TM receptor; cholinergic receptor, muscarinic 2; CHRM2; FLJ43243; HM2; mAChR M2; MGC120006; MGC120007; muscarinic acetylcholine receptor M2; muscarinic M2 receptor

Molecular Weight

Mass (kDA):
51.715 kDA

Genomic Context


Human

Location:	7q33
Sequence:	7; NC_000007.14 (136868637..137020255)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Phosphorylation in response to agonist binding promotes receptor internalization.

Diseases

Depressive Disorder
Mental Disorders
Major Depressive Disorder
Substance-related Disorders
Dysequilibrium Syndrome
Nervousness
Social Disinhibition
Personality Disorders
Antisocial Personality Disorder
Hereditary Diseases
Nicotine Dependence

Inflammation
Cardiac Arrhythmia
Depressive Syndromes
Bipolar Disorder
Schizophrenia
Cognition Disorders

Pathways

Cognition
Pathogenesis
Methylation
System Development
Prepulse Inhibition
Nervous System Development
Glycosylation
Response To Nicotine

Central Nervous System Development
Innervation
Localization

PTMs

Methylation

Research Areas

GPCR
Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHRM2

References

PMID: 3037705 by Bonner T.I., et al. Identification of a family of muscarinic acetylcholine receptor genes.

PMID: 3443095 by Peralta E.G., et al. Distinct primary structures, ligand-binding properties and tissue- specific expression of four human muscarinic acetylcholine receptors.