Beta-chimaerin Antibodies

AND CHN2 ELISA kits, Beta-chimaerin Proteins

Many biological assays use antibodies to detect Beta-chimaerin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Beta-chimaerin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Beta-chimaerin antibodies...

We validate the specificity of these antibodies to Beta-chimaerin by testing them on tissues known to express CHN2 positively and negatively. Browse below to find the CHN2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CHN2 Infographic by Boster Bio

All CHN2 Products

Product

Figures

Specificity

Applications

Price

Chimaerin 2 (CHN2) (NM_004067) Human Recombinant Protein

$1249
Cat # PROTP52757
20 µg

Chimaerin 2 (CHN2) (NM_004067) Human Over-expression Lysate

Human

$628
Cat # LS001124
100 µg

CHN2 Overview

Facts about Beta-chimaerin.

CHN2 3D structure. Source: alphafold

Beta-chimaerin (CHN2)

GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to greater Rac activity and could therefore play a role in the development from low-grade to high-grade tumors.

Gene Information

Human
Gene Name:	CHN2
Uniprot:	P52757
Entrez:	1124

Family

Belongs to:

No superfamily

Alternative Names

ARHGAP3beta chimerin; BCH; beta-chimaerin; beta-chimerin; chimerin (chimaerin) 2; MGC138360; Rho GTPase-activating protein 3; RHOGAP3; rho-GTPase-activating protein 3

Molecular Weight

Mass (kDA):
53.924 kDA

Genomic Context


Human

Location:	7p14.3
Sequence:	7; NC_000007.14 (29146547..29514335)

Subcellular Localizations

Membrane; Peripheral membrane protein.

Diseases

Diabetes Mellitus
Kidney Diseases
Diabetic Nephropathy
Neoplasms
Diabetes Mellitus, Non-insulin-dependent
Proteinuria Of Undiagnosed Cause
Nephropathy Toxic
Prion Diseases
Encephalopathy, Bovine Spongiform
Malignant Neoplasm Of Kidney
Tumor Progression
Neurodegenerative Disorders

Malignant Neoplasm Of Breast
Bone Neoplasms
Fetal Growth Retardation
Carcinogenesis
Insulin Resistance
Giant Cell Tumors
Glomerulonephritis

Interacting Proteins

NCK2
RAC1

Pathways

Cell Proliferation
Pinocytosis
Platelet Activation
Pathogenesis
Bone Resorption
Excretion

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHN2

References

PMID: 8175705 by Leung T., et al. Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras- related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain.

PMID: 7614486 by Yuan S., et al. Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma.