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- Table of Contents
Facts about Charged multivesicular body protein 2b.
The MVB pathway seems to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate in the invaginating membrane before the ILV is discharged.
Human | |
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Gene Name: | CHMP2B |
Uniprot: | Q9UQN3 |
Entrez: | 25978 |
Belongs to: |
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SNF7 family |
charged multivesicular body protein 2b; CHMP2.5; CHMP2.5VPS2BVPS2-2; CHMP2B; chromatin modifying protein 2B; Chromatin-modifying protein 2b; DKFZP564O123; DMT1; hVps2-2; Vacuolar protein sorting-associated protein 2-2; vacuolar protein-sorting-associated protein 2-2; VPS2 homolog B; Vps2-2; VPS2B
Mass (kDA):
23.907 kDA
Human | |
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Location: | 3p11.2 |
Sequence: | 3; NC_000003.12 (87227309..87255556) |
Widely expressed. Expressed in brain, heart, skeletal muscle, spleen, kidney, liver, small intestine, pancreas, lung, placenta and leukocytes. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal chord, occipital lobe, frontal lobe, temporal lobe and putamen.
Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein.
PMID: 14519844 by Martin-Serrano J., et al. Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.
PMID: 16041373 by Skibinski G., et al. Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia.