CHM Antibodies

Rab proteins geranylgeranyltransferase component A 1 (CHM)

Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complicated. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic part B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer response.

The component A is believed to be regenerated by shifting its prenylated Rab back to the donor membrane. In any case, a pre-formed complex comprising CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternate pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.

Gene Information

Human
Gene Name:	CHM
Uniprot:	P24386
Entrez:	1121

Family

Belongs to:
Rab GDI family

Alternative Names

choroideraemia protein; choroideremia (Rab escort protein 1); Rab geranylgeranyltransferase component A; rab proteins geranylgeranyltransferase component A 1; REP1

Molecular Weight

Mass (kDA):
73.476 kDA

Genomic Context

Human
Location:	Xq21.2
Sequence:	X; NC_000023.11 (85861180..86047558, complement)

Subcellular Localizations

Cytoplasm, cytosol.

Diseases

• Choroideremia
• Hydatidiform Mole
• Complete Hydatidiform Mole
• Neoplasms
• Uterine Neoplasms
• Gestational Trophoblastic Neoplasms
• Malignant Neoplasms
• Partial Hydatidiform Mole
• Blind Vision
• Choriocarcinoma
• Pain
• Neoplasm Metastasis

• Atrophy
• Trophoblastic Neoplasms
• Triploidy
• Retinal Degeneration
• Chorioretinal Atrophy
• Carcinoma
• Dystrophy

Interacting Proteins

• RABGGTA

Pathways

• Prenylation
• Transport
• Pathogenesis
• Cell Cycle
• Fermentation
• Translation
• Localization
• Fertilization
• Blood Circulation
• Cell Death
• Secretion
• S Phase
• Cell Killing

• Cell Growth
• Vasculogenesis
• Cell Differentiation
• Cell Proliferation
• Dna Repair
• Ovulation
• Excretion

PTMs

• Prenylation
• Geranylgeranylation
• Oxidation

• Cleavage
• Phosphorylation
• Methylation

• Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHM

Best Uses Of The CHM Marker From Boster Bio

If you're looking to determine the presence of a protein using ELISA or WB, IHC, or ELISA kits, Boster Bio has the products that meet your requirements. Boster Bio's Anti-Bax Antibody Picoband and PICOKINE(tm) ELISA kits are ideal for these types of applications. To receive product credits or product recognition You can also submit your results to species-specific samples applications, and ELISA. The Boster Bio CHM Marker is a versatile instrument with numerous applications and is accessible to all scientists around world.

Boster Bio's products are optimized for WB, IHC, ELISA, PICOKINE(tm) ELISA kits and PICOBAND(tm)

Boster Bio has mastered the process of coating ELISA plates to facilitate high-affinity Blot detection. ELISA can be used to detect soluble proteins. Guides to sample preparation will assist you in preparing your samples correctly and provide more reliable results. Boster Bio offers step-by-step guidance to help you with ELISA data analysis.

ELISA is a powerful tool to conduct research. Picokine(r) Quick ELISA provides excellent results in just 90 minutes. The simplified protocol ensures excellent sensitivity and reproducibility. This high-sensitivity kit has been tested on multiple biological samples and guarantees reproducibility.

Boster Bio's Anti-Bax Antibody Picoband

Boster Bio's Anti-BaX Antibody Picoband is a highly sensitive ELISA kit specifically designed to detect levels of Bax. The product has been tested against both positive and negative samples. The Picoband's sensitiveness is increased to levels of a picogram that can save up to 30 minutes of immunohistochemistry (IHC). Boster Bio's Anti-Bax Antibody Picoband has been evaluated using positive and negative samples to ensure high affinity and optimum specificity. Boster rewards first-time reviewers of their products with product credit, and also rewards scientists from all over the world for their input.

Boster Bio was founded by famous histologist Steven Xia in 1993. Boster Bio is a leader in high-affinity, high-specificity antibodies and ELISA kit manufacturing. Their products are validated transparently for various applications, including Flow Cytometry. Boster Bio is committed in offering top-quality antibodies that are in line with the highest standards of quality. Boster Bio offers a Boster Quality Warranty. It also expands its product offerings each month.

Boster Bio's PICOKINE(tm) ELISA kits

Boster Bio manufactures antibodies and ELISA kits to detect of biomarkers in cancer, neuroscience inflammation, as well as development biology. These kits are highly sensitive and can detect biomarkers in the picogram scale. Boster Bio immunological Reagents are available through Tebu-bio. The company's PICOKINE(tm) ELISA kits for the CHM marker were designed for use in research labs and clinical labs.